摘要
随着基因组学的不断发展,研究者们对非小细胞肺癌的致病机制有了更深层次的认识。相应地,非小细胞肺癌驱动基因与中医证型之间是否存在相关性亦引起了中西医学者密切关注。通过检索万方数据、中国知网、重庆维普、考克兰图书馆(Cochrance Library)、美国生物技术信息中心下属的医学图书检索系统(PubMed)、荷兰医学文摘数据库(Embase)6个数据库尚未发现有非小细胞肺癌驱动基因与中医证型相关性研究进展综述,故该文系统梳理了肺癌主要驱动基因突变的中医证型研究,发现EGFR基因突变的肺癌患者中医证型主要以气阴两虚证和脾虚痰湿证最为常见;EML4-ALK融合基因、KRAS基因突变的肺癌患者中医证型研究较少且未达成共识;对于突变率小于5%的驱动基因BRAF、ROS1、HER2、RET、NTRK、MET阳性肺癌患者的中医证型尚未有研究报道。同时,期望该文能为非小细胞肺癌驱动基因突变的中医辨证分型研究提供线索和在精准靶向时代拓展中西医结合诊断治疗新思路。
With the development of genomics,researchers have a deeper understanding of the pathogenesis of non-small cell lung cancer.Accordingly,whether there is a correlation between the non-small cell lung cancer driver gene and TCM syndrome has also attracted the close attention of Chinese and Western medicine scholars.By searching Wanfang Data,China National Knowledge Infrastructure(CNKI),Chongqing VIP,Cochrane Library,American Biotechnology Information Center's medical library retrieval system(PubMed),the Netherlands Medical Abstracts Database(Embase)have not yet found the driver gene of non-small cell lung cancer and TCM syndrome correlation research review.Therefore,this paper systematically combs the research on the TCM syndromes of the main driver gene mutations of lung cancer and finds that the TCM syndromes of lung cancer patients with EGFR gene mutations are mainly Qi and Yin deficiency syndrome and spleen deficiency and phlegm-dampness syndrome.The research on EML4-ALK fusion gene and KRAS gene mutation in patients with lung cancer syndromes is less and there is no consensus.There have been no research reports on the traditional Chinese medicine syndrome types of lung cancer patients with BRAF,ROS1,HER2,RET,NTRK and MET positive driver genes with mutation rates less than 5%.At the same time,it is expected that this paper could provide clues for the study of TCM syndrome differentiation of non-small cell lung cancer driver gene mutations and expand new ideas for the diagnosis and treatment of integrated traditional Chinese and Western medicine in the era of precise targeting.
作者
蒋凤仙
禚孝丽
赖靖江
王景亮
刘寨东
付国斌
JIANG Fengxian;ZHUO Xiaoli;LAI Jingjiang;WANG Jingliang;LIU Zhaidong;FU Guobin(Department of Oncology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong,China;The Second Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250002,Shandong,China;Department of Clinical Medicine,Shandong First Medical University(Shandong Academy of Medical Sciences),Jinan 250117,Shandong,China;Department of Oncology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;Department of Oncology,Shandong Provincial Hospital,Shandong University,Jinan 250021,Shandong,China)
出处
《辽宁中医杂志》
北大核心
2024年第5期201-205,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81802284)
泰山学者青年专家计划项目(202103179)
山东省医学会临床科研资金项目(YXH2022ZX02176)
山东省中医药科技项目(2020M015)
山东省名老中医药专家(齐元富)传承工作室项目
北京市希思科临床肿瘤学研究基金项目(Y-HR2022MS-0257)
关键词
非小细胞肺癌
驱动基因
中医证型
non-small cell lung cancer
driver genes
traditional Chinese medicine syndrome type
