摘要
卵泡发育异常是子宫内膜异位症(endometriosis,EMs)合并不孕的病理机制之一。近年,环状RNA(circular RNA,circRNA)在子宫内膜相关疾病发生过程中的作用日益引起关注,但是circRNA在EMs中的研究尚处于起步阶段,尤其是circRNA在EMs卵泡发育中的作用仍不明确。目前已知circRNA能够通过影响卵泡颗粒细胞增殖与凋亡、上皮-间质转化以及卵泡液微环境和激素调节,参与EMs的发生发展过程,并进一步导致不孕。阐述circRNA可能影响卵泡颗粒细胞从而导致不良妊娠结局的研究进展,探讨circRNA作为EMs生物标志物的可能性,以期为临床提供诊治的新思路和新方法。
The abnormal follicular development is one of the pathological mechanisms of infertility in patients with endometriosis(EMs).In recent years,the role of circular RNA(circRNA)in the development of endometrium-related diseases has attracted more attention.However,the research on the role of circRNAs in EMs is still at the early stage,and the role of circRNA in the development of EMs follicles is especially unclear.It is currently known that circRNAs can participate in the occurrence and development of EMs by affecting the proliferation and apoptosis of granulosa cells,epithelial-mesenchymal transition,microenvironment of follicular fluid and hormone regulation,which further lead to infertility.This review aims to elucidate the research progress on the potential impact of circRNAs on follicular granulosa cells leading to adverse pregnancy outcomes,and to explore the possibility of circRNAs as a biomarker for EMs,so as to provide new ideas and methods for clinical diagnosis and treatment.
作者
高朝阳
章宁晴
陈琼华
吴荣锋(审校)
GAO Zhaoyang;ZHANG Ning-qing;CHEN Qiong-hua;WU Rong-feng(Reproductive Medicine Center,Department of Obstetrics and Gynecology,The First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University,Xiamen 361003,Fujian Province,China)
出处
《国际生殖健康/计划生育杂志》
2024年第3期243-248,共6页
Journal of International Reproductive Health/Family Planning
基金
国家自然科学基金(82171638)
福建省自然科学基金面上项目(2023J011619)
厦门市医疗卫生指导性项目(3502Z20214ZD1008)
