摘要
目的分析帕金森病患者采用多巴丝肼与艾司西酞普兰联合治疗的临床效果。方法选取广州医科大学附属清远医院(清远市人民医院)在2020年1月至2024年6月间收治的30例帕金森患者,采用随机数字表法分为两组,各15例。对照组给予多巴丝肼治疗,观察组给予多巴丝肼结合艾司西酞普兰治疗。对比两组:(1)治疗效果;(2)不良反应;(3)认知功能;(4)临床症状;(5)心理状态;(6)炎症因子水平。结果与对照组相比,观察组治疗有效率更高,P<0.05;两组不良反应发生率对比,P>0.05。两组干预前MoCA、UPDRS、HAMA、HAMD评分、IL-5、TNF-ɑ水平对比,P>0.05;两组干预后MoCA评分对比,观察组比对照组高,其余指标对比,观察组均比对照组低,P<0.05。结论:多巴丝肼结合艾司西酞普兰治疗帕金森患者,可改善患者认知功能、临床症状与心理状态,降低炎症因子水平,提高治疗效果。
Objective:To analyze the clinical effect of the combination therapy of dopa-hydrazine and escitalopram in patients with Parkinson's disease.Methods:Thirty patients with Parkinson's disease admitted to Qingyuan Hospital affiliated to Guangzhou Medical University from January 2020 to June 2024 were randomly divided into two groups,15 patients in each group.The control group was treated with dobutamine,and the observation group was treated with dobutamine combined with escitalopram.Compare the two groups:①therapeutic effect;②Adverse reactions;③Cognitive function;④Clinical symptoms;⑤Psychological state;⑥Levels of inflammatory factors.Results:Compared with the control group,the effective rate in the observation group was higher,P<0.05.The incidence of adverse reactions between the two groups was compared,P>0.05.The levels of MoCA、UPDRS、HAMA、HAMD、IL-5 and TNF-αwere compared between the two groups before intervention,P>0.05;After intervention,the MoCA score of the observation group was higher than that of the control group,and the other indexes were lower in the observation group than that of the control group,P<0.05.Conclusion:Dopamine combined with Escitalopram can improve the cognitive function,clinical symptoms and psychological state of patients with Parkinson's disease,reduce the level of inflammatory factors and improve the therapeutic effect.
作者
何静薇
刘锦仪
邱素丽
He Jingwei;Liu Jinyi;Qiu Suli(Department of Neurology,Qingyuan Hospital affiliated to Guangzhou Medical University(Qingyuan People's Hospital),Qingyuan Guangdong 511518,China)
出处
《生命科学仪器》
2024年第6期181-183,共3页
Life Science Instruments
