摘要
Background:Little is known about the characteristics of patients with psoriatic arthritis(PsA)during the coronavirus disease 2019(COVID-19)pandemic.This study aimed to evaluate the impact of COVID-19 on PsA progression and comprehend the role of COVID-19 vaccination in the infection course.Methods:A total of 163 adult patients with PsA from 15 province-level regions in China were enrolled in this multiregional observational study from January 14,2023,to March 22,2023.Data on patient demographics,COVID-19 status,and disease characteristics were collected through a structured questionnaire survey.Results:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections could worsen PsA,with 29.0%(36/124)of patients experiencing deteriorating symptoms.Psoriasis was the symptom that was most exacerbated(22,61.1%),followed by peripheral arthritis(19,52.8%)and dactylitis(9,25.0%).Compared with the patients whose arthritic condition was stable before contracting COVID-19,those with active PsA experienced more severe COVID-19 symptoms,reporting higher self-assessed symptom severity scores and a greater prevalence of dyspnea(42.9%[6/14]vs.7.3%[9/123]).Moreover,although full vaccination(≥2 doses)could not prevent COVID-19,it could alleviate the infection symptoms,including diarrhea,fatigue,appetite changes,and axial joint pain.Additionally,fully vaccinated individuals had a higher probability of avoiding deterioration of their PsA condition after infection.Conclusions:Active PsA and lack of COVID-19 vaccination are risk factors for worsening COVID-19 symptoms and PsA condition after infection.The evidence from this real-world study suggests that COVID-19 may exacerbate PsA.
基金
Funding information National Key Research and Development Program of China,Grant/Award Number:2022YFC3602000
National Natural Science Foundation of China,Grant/Award Number:81871281
Beijing Science and Technology Planning Project,Grant/Award Number:Z191100006619111。
