摘要
目的:探讨动态对比增强磁共振成像(DCE-MRI)参数诊断结直肠癌术前TN分期的价值。方法:对我院2021年5月—2023年5月80例结直肠癌患者的临床资料进行回顾性分析,患者均行常规MRI及DCE-MRI扫描检查,以病理学诊断结果为金标准,比较不同TN分期患者DCE-MRI参数(容量转移常数(K^(trans))、速率常数(K_(ep))、血管外/细胞外间隙容积分数(V_(e))),采用受试者工作曲线(ROC)分析DCE-MRI参数对TN分期的诊断价值,采用相关性系数分析DCE-MRI参数与结直肠癌患者TN分期的相关性。结果:病理学诊断结果显示,80例结直肠癌患者中,T1期27例、T2期21例、T3期17例、T4期15例;N0期41例、N1期21例、N2期18例;不同T分期结直肠癌患者K^(trans)、K_(ep)、V_(e)比较,差异有统计学意义(P<0.05);ROC曲线显示,K^(trans)、K_(ep)、V_(e)联合诊断结直肠癌患者T1-2及T3-4的AUC为0.896,高于三者单独诊断的0.783、0.774、0.718(P<0.05);不同N分期结直肠癌患者K^(trans)、K_(ep)、V_(e)比较,差异有统计学意义(P<0.05);ROC曲线显示,K^(trans)、K_(ep)、V_(e)联合诊断结直肠癌患者N0及N1-2的AUC为0.918,高于三者单独诊断的0.817、0.763、0.779(P<0.05);Spearman相关性分析结果显示,K^(trans)、K_(ep)、V_(e)与结直肠癌患者TN分期呈正相关(P<0.05)。结论:DCE-MRI参数对结直肠癌术前TN分期具有较高的诊断价值,可为临床制定治疗方案提供依据。
Objective:To explore the value of dynamic contrast enhanced-MRI(DCE-MRI)parameters in the diagnosis of preoperative TN staging in colorectal cancer.Methods:A retrospective analysis was performed on the clinical data of 80 patients with colorectal cancer in our hospital between May 2021 and May 2023.All patients underwent routine MRI and DCE-MRI scans.Taking pathological diagnosis results as the golden standard,DCE-MRI parameters(volume transfer constant(K^(trans))rate constant(K_(ep)),extravascular extracellular volume fraction(V_e))in patients with different TN staging were compared.The correlation between DCE-MRI parameters and TN staging was analyzed by correlation coefficient.The diagnostic value of DCE-MRI parameters for TN staging was analyzed by receiver operating characteristic(ROC)curves.Results:The results of pathological diagnosis showed that in the 80 patients with colorectal cancer,there were 27 cases in stage T1,21 cases in stage T2,17 cases in stage T3,15 cases in stage T4.41 cases in stage N0,21 cases in stage N1 and 18 cases in stage N2.There were significant differences in K^(trans),K_(ep)and V_eamong colorectal cancer patients with different T staging(P<0.05).ROC curves analysis showed that AUC of K^(trans)combined with K_(ep)and V_ein the diagnosis of T1-2 and T3-4 was 0.896,which was greater than that of single index(0.783,0.7740.718;P<0.05).There were significant differences in K^(trans),K_(ep)and V_eamong colorectal cancer patients with different N staging(P<0.05).ROC curves analysis showed that the AUC of K^(trans)combined with K_(ep)and V_ein the diagnosis of N0 and N1-2 was 0.918,which was greater than that of single index(0.817,0.763,0.779;P<0.05).The results of Spearman correlation analysis showed that K^(trans),K_(ep)and V_ewere positively correlated with TN staging in colorectal cancer patients(P<0.05).Conclusion:DCE-MRI parameters have high diagnostic value for preoperative TN staging in patients with colorectal cancer,which can provide basis for the formulation of clinical treatment regimens.
作者
蒋蕾
卢禹
石梦园
JIANG Lei;LU Yu;SHI Meng-yuan(Department of Medical Technology,Nanyang Medical College,Nanyang Henan 473000,China;MRI Room,the First Affiliated Hospital of Nanyang Medical College,Nanyang Henan 473000,China)
出处
《中国临床医学影像杂志》
北大核心
2025年第1期38-42,共5页
Journal of China Clinic Medical Imaging
基金
河南省终身教育课题(202370016)
河南省高等教育教学改革研究与实践项目(2021SJGLX806)
河南省职业教育教学改革研究与实践项目(202405851)
南阳医专教育教学改革研究与实践项目(JGXM202417)。
关键词
结直肠肿瘤
肿瘤分期
磁共振成像
Colorectal Neoplasms
Neoplasm Staging
Magnetic Resonance Imaging
