摘要
目的 分析总胆固醇(TC)/高密度脂蛋白胆固醇(HDL-C)比值与围绝经期女性心血管事件的相关性。方法 选择2021年1月至2023年11月邢台市人民医院接诊的142例围绝经期女性作为研究对象,并根据是否发生心血管事件分为发生组(n=28)与未发生组(n=114)。所有研究对象入院后均检测血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)水平,并计算TC/HDL-C。分析比较各组一般资料、生化指标及TC/HDL-C,采用受试者工作特征(ROC)曲线评估TC/HDL-C对围绝经期女性心血管事件发生的预测价值;采用多因素Logistic回归分析影响围绝经期女性心血管事件发生的相关因素。结果 发生组围绝经期女性卵泡刺激素(FSH)、雌二醇(E_(2))、孕酮(P)、黄体生成激素(LH)、HDL-C水平均低于未发生组,高血压史占比、糖尿病史占比、低骨密度占比及甘油三酯(TG)、TC、低密度脂蛋白胆固醇(LDL-C)、TC/HDL-C、同型半胱氨酸(Hcy)水平均高于未发生组(均P <0.05)。ROC曲线结果显示,TC/HDL-C预测围绝经期女性心血管事件发生的曲线下面积(AUC)为0.910,95%CI为0.860~0.960。多因素Logistic回归分析显示,低骨密度(OR=2.423,95%CI:1.535~3.825)、高血压史(OR=2.098,95%CI:1.451~3.033)、糖尿病史(OR=2.707,95%CI:1.655~4.428)、FSH <3.68μg/L(OR=2.787,95%CI:1.687~4.603)、E_(2) <25.64ng/mL(OR=2.904,95%CI:1.744~4.834)、Hcy≥12.66 mmol/L(OR=3.142,95%CI:1.837~5.377)、TC/HDL-C≥2.55(OR=3.766,95%CI:2.003~7.079)均为围绝经期女性心血管事件发生的危险因素(P <0.05)。结论 TC/HDL-C水平升高与围绝经期女性心血管事件的发生密切相关,是心血管事件发生的危险因素,有助于为临床预测围绝经期女性心血管事件发生提供指导。
Objective To analyze the correlation between the total cholesterol(TC)/high density lipoprotein cholesterol(HDL-C)ratio and cardiovascular events in perimenopausal women.Methods A total of 142 perimenopausal women who were received by Xingtai People's Hospital from January 2021 to November 2023 were selected as the study subjects and were divided into the occurrence group(n=28)and the non-occurrence group(n=114)according to whether cardiovascular events occurred.Serum TC and HDL-C levels were measured in all subjects after admission,and the TC/HDL-C was calculated.The general data,biochemical indexes,and TC/HDL-C were analyzed and compared among all groups.The receiver operating characteristic curve(ROC)was used to evaluate the predictive value of TC/HDL-C for the occurrence of cardiovascular events in perimenopausal women.Multiple Logistic regression was used to analyze the related factors affecting the occurrence of cardiovascular events in perimenopausal women.Results The levels of follicle stimulating hormone(FSH),estradiol(E_(2)),progesterone(P),luteinizing hormone(LH)and HDL-C in perimenopausal women in the occurrence group were lower than those in the non-occurrence group,while the proportions of hypertension history,diabetes history,low bone mineral density,and the levels of triglyceride(TG,)TC,low density lipoprotein cholesterol(LDL-C),TC/HDL-C,and Hcy were higher than those in the non-occurrence group(all P<0.05).The ROC curve results showed that the area under the curve(AUC)of TC/HDL-C for predicting the occurrence of cardiovascular events in perimenopausal women was 0.910(95%confidence interval[CI]:0.860-0.960).Multiple Logistic regression analysis showed that low bone mineral density(odds ratio[OR]=2.423,95%CI:1.535-3.825),history of hypertension(OR=2.098,95%CI:1.451-3.033),history of diabetes(OR=2.707,95%CI:1.655-4.428),FSH<3.68μg/L(OR=2.787,95%CI:1.687-4.603),E_(2)<25.64 ng/ml(OR=2.904,95%CI:1.744-4.834),Hcy≥12.66 mmol/L(OR=3.142,95%CI:1.837-5.377),and TC/HDL-C≥2.55(OR=3.766,95%CI:2.003-7.079)were risk factors for the occurrence of cardiovascular events in perimenopausal women(P<0.05).Conclusion The increase in TC/HDL-C level is closely related to the occurrence of cardiovascular events in perimenopausal women and is a risk factor for cardiovascular events,which is helpful to provide guidance for the clinical prediction of cardiovascular events in perimenopausal women.
作者
谷亚楠
赵建英
张丽娜
曹岚
GU Ya'nan;ZHAO Jianying;ZHANG Lina;CAO Lan(Department of Clinical Laboratory,Xingtai People's Hospital,Xingtai,Hebei 054001,China;Health Examination Center,Xingtai People's Hospital,Xingtai,Hebei 054001,China;Department of Endocrinology,Xingtai People's Hospital,Xingtai,Hebei 054001,China)
出处
《转化医学杂志》
2024年第9期1479-1483,1488,共6页
Translational Medicine Journal
基金
2022年邢台市市级科技计划自筹经费项目(2022ZC077)。
