摘要
肝脏移植手术在终末期肝脏疾病治疗领域有着举足轻重的地位,是目前能够切实挽救终末期肝脏疾病患者生命且唯一被临床实践充分证实为有效的治疗手段。然而,肝脏移植术后的感染问题成为阻碍患者良好预后的关键因素之一。其中,供者来源感染因其独特性和复杂性,正逐渐成为临床和科研领域的研究热点。笔者通过对大量现有研究进行系统且全面的综合分析,深入剖析肝脏移植术后感染的整体现状,明确供者来源感染的具体类型以及其各自所呈现的特征。在此基础上,深入探讨该类感染的潜在风险,并针对性地提出预防性使用抗生素、疫苗接种等预防策略,力求最大程度地改善肝脏移植术后患者的预后状况,提升患者的生存质量。
Liver transplantation plays a pivotal role in the field of treating end-stage liver diseases.It is currently the only treatment method that can effectively save patients’lives and has been fully verified as effective in clinical practice.However,the problem of postoperative infection has become one of the key factors impeding the favorable prognosis of patients.Among them,donor-derived infections,due to their uniqueness and complexity,are gradually becoming a research hotspot in both clinical and scientific research fields.Through a systematic and comprehensive analysis of a large number of existing studies,we deeply analyzed the overall current situation of infections after liver transplantation,clarified the specific types of donor-derived infections and their respective characteristics.On this basis,the potential risks of such infections were thoroughly explored,and preventive strategies such as the prophylactic use of antibiotics and vaccination were put forward in a targeted manner,aiming to improve the prognosis of patients after liver transplantation to the greatest extent and enhance the quality of life of patients.
作者
杨镓
孔凌祥
徐西
徐岗
袁京生
吕涛
杨俭
杨家印
YANG Jia;KONG Lingxiang;XU Xi;XU Gang;YUAN Jingsheng;LÜTao;YANG Jian;YANG Jiayin(Liver Transplant Center,Organ Transplant Center,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,P.R.China)
出处
《中国普外基础与临床杂志》
2025年第1期22-27,共6页
Chinese Journal of Bases and Clinics In General Surgery
基金
四大慢病重大专项(项目编号:2023ZD0502400)
四川省科技厅重点研发项目(项目编号:2024YFFK0312)
国家自然科学基金面上项目(项目编号:82070674、82270691)。
关键词
肝脏移植
供者来源性感染
器官保存液
liver transplantation
donor-derived infection
organ preservation solution
