摘要
非洲猪瘟(African swine fever, ASF)是由非洲猪瘟病毒(African swine fever virus, ASFV)感染所引起的一种家猪和各种野猪急性出血的传染性疾病,由于高发病率和高致死性的特性对全球家猪养殖产业造成严重的经济损失。ASFV编码蛋白高达150多种,而ASFV结构蛋白作为病毒粒子的主要组成部分,在协助病毒吸附入侵宿主细胞、促进子代病毒颗粒复制、组装以及释放等过程发挥着重要作用。研究表明,病毒结构蛋白可通过与宿主蛋白的相互作用,促进病毒入侵、增殖、影响病毒毒力以及拮抗宿主免疫反应等。因此,本文通过概述ASFV结构蛋白与宿主蛋白的相互作用及其机制,为研究ASFV的致病机制以及ASF的防治提供参考。
African swine fever(ASF)is a highly contagious disease characterized by severe bleeding in both domestic pigs and various wild boars caused by infection with the African swine fever virus(ASFV).The global pig breeding industry has suffered significant economic losses due to the high morbidity and mortality rates associated with ASF.ASFV contains over 150 different proteins,with its structural proteins playing a crucial role in facilitating the virus’s attachment to and entry into host cells,as well as in the replication,assembly,and release of new viral particles.Research has demonstrated that these viral structural proteins can enhance virus invasion and replication,impact viral virulence,and counteract the host immune response through interactions with host proteins.This review summarizes the interactions between ASFV structural proteins and host proteins,along with their underlying mechanisms,in order to contribute to the understanding of ASFV pathogenesis and the development of strategies for its prevention and treatment.
作者
张素
孙丽芳
李兰兰
吴琳娇
陈磊清
吴允昆
ZHANG Su;SUN Lifang;LI Lanlan;WU Linjiao;CHEN Leiqing;WU Yunkun(College of Life Sciences,Fujian Normal University,Fuzhou 350108,China)
出处
《畜牧兽医学报》
北大核心
2025年第1期95-106,共12页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
关键词
非洲猪瘟病毒
结构蛋白
宿主蛋白
蛋白相互作用
African swine fever virus(ASFV)
structural protein
host protein
proteinprotein interaction
