摘要
目的观察疏肝健脾颗粒对轻中度特应性皮炎(Atopic dermatitis,AD)合并睡眠障碍(Sleep disturbances,SDs)患者的临床疗效并探讨其作用机制。方法将符合诊断与纳入标准的58例轻中度成人AD合并SDs患者随机分为治疗组与对照组,每组29例。治疗组予疏肝健脾颗粒联合除湿止痒软膏干预,对照组予盐酸西替利嗪片联合除湿止痒软膏干预,均持续4周。观测、比较两组患者治疗前后特应性皮炎指数(SCORAD)评分、失眠严重程度指数(ISI)评分及医院焦虑抑郁量表(HADS)评分差异;检测、比较血常规及肝肾功能指标、血清5-羟色胺(5-HT)、超氧化物歧化酶(SOD)及丙二醛(MDA)含量差异。对上述评分与指标进行相关性分析。结果经4周干预,对照组总有效率为65.52%,治疗组总有效率为89.66%,显著优于对照组(P<0.05)。与干预前相比,两组的SCORAD、ISI、HADS评分与血清MDA含量均显著降低,血清5-HT及SOD含量均有升高。其中,治疗组疗后SCORAD(P<0.05)、ISI(P<0.01)评分显著低于对照组,血清SOD含量显著高于对照组(P<0.05)。患者血清5-HT含量与ISI评分呈负相关(r=-0.342,P<0.01);SOD含量与SCORAD评分呈负相关(r=-0.277,P<0.05),与ISI评分呈负相关(r=-0.311,P<0.01);MDA含量与SCORAD评分呈正相关(r=0.329,P<0.01)。疏肝健脾颗粒安全性良好,干预前后血常规及肝、肾功能未见异常改变。结论疏肝健脾颗粒对轻中度AD合并SDs患者疗效显著,其机制可能与抑制氧化应激反应、调节血清5-HT胺含量有关。
Objective To observe the clinical efficacy and explore antioxidant mechanism of Shugan Jianpi granules in treating atopic dermatitis(AD)combined with sleep disturbances(SDs).Methods 58 adult patients meeting the inclusion criteria for mild to moderate AD with SDs were randomly assigned to a treatment group and a control group,with 29 patients in each group.Both groups underwent a 4-week intervention.The treatment group received Shugan Jianpi granules in combination with Chushi Zhiyang ointment,while the control group received Cetirizine Hydrochloride tablets in combination with Chushi Zhiyang ointment.This study assessed and compared the differences in atopic dermatitis index(SCORAD)scores,insomnia severity index(ISI)scores,and hospital anxiety and depression scale(HADS)scores,routine blood tests,liver and kidney function indicators,serum levels of 5-HT,SOD,and MDA between two groups before and after treatment.A correlation analysis was conducted on the aforementioned scores and indicators.Results The treatment group showed a total effective rate of 89.66%,which is significantly higher than 65.52%observed in the control group(P<0.05).Following the interventions,both groups exhibited a significant reduction in scores of SCORAD,ISI,and HADS,as well as a notable decrease in serum levels of MDA.Concurrently,increased serum levels of 5-HT and SOD were observed in the groups.The treatment group exhibited significantly decreased SCORAD(P<0.05)and ISI(P<0.01)scores and increased serum SOD levels(P<0.05)compared to the control.Additionally,the patients'ISI scores were negatively correlated with serum 5-HT(r=-0.342,P<0.01)and SOD(r=-0.311,P<0.01)levels,while the SCORAD scores were positively correlated with MDA(r=0.329,P<0.01)but negatively correlated with SOD(r=-0.277,P<0.05)levels.Shugan Jianpi granules were also found to be safe throughout the treatment.Conclusion Shugan Jianpi granules have demonstrated notable efficacy in AD complicated by SDs,which may be attributed to its capacity to elevate serum 5-HT levels and reduce oxidative stress.
作者
尹强
李丹阳
段行武
周思瑶
吴治民
赵久丽
YIN Qiang;LI Danyang;DUAN Xingwu;ZHOU Siyao;WU Zhimin;ZHAO Jiuli(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)
出处
《中国中医基础医学杂志》
2025年第1期94-98,共5页
JOURNAL OF BASIC CHINESE MEDICINE
基金
国家自然科学基金面上项目(82074436)
国家中医药管理局中医药行业科研专项(2015468001)。
