摘要
富氢水具有良好的抗菌、抗炎、抗氧化及促进伤口愈合等作用,在脑损伤、肾损伤等多种疾病的治疗中发挥积极效应。在牙周炎的治疗中,富氢水也具有一定的临床应用潜力。目前研究认为,富氢水可抑制牙周致病菌生物膜形成,抑制口腔结缔组织及骨组织破坏,对炎症及氧化应激相关的牙周炎具有潜在治疗作用。富氢水通过抑制氧化应激反应,上调抗氧化酶如谷胱甘肽过氧化物酶(glutathione peroxidase,GPX)、超氧化物歧化酶(superoxide dismutase,SOD)表达,减轻牙周炎环境下的牙周组织损伤。调节与炎症密切相关的核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)抗氧化防御通路和丝裂原活化蛋白激酶(mitogenactivated protein kinase,MAPK)信号通路,抑制炎症细胞因子如白细胞介素(interleukin,IL)的表达,是富氢水发挥抗炎作用的主要机制。在菌斑生物膜的形成中,富氢水可以抑制细菌生长增殖,并下调糖基转移酶(glycosyltransferase,GTFs)和葡聚糖结合蛋白(glucan-binding protein,GBP)以抑制细菌黏附,预防牙周炎发生。此外,富氢水对多种细胞生长因子、α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)和I型胶原表达也具有积极作用,可以促进伤口愈合。目前临床研究中尚未发现富氢水使用的不良反应,其生物安全性能够得到一定保证,但有关富氢水在牙周炎中的研究多为体内外临床前研究,且对于富氢水在治疗中的有效浓度和剂量的选择仍不明确,需要进一步研究证明富氢水在牙周炎中的治疗意义,并探究富氢水的最佳使用方案。本文旨在对目前富氢水在牙周炎治疗中的作用及机制进行综述。
Hydrogen-rich water(HRW)shows excellent antibacterial,anti-inflammatory,antioxidant,and wound-healing properties and plays a positive role in the treatment of various diseases,such as brain injury,kidney injury,and periodontitis.Current studies found that HRW can inhibit periodontopathogenic biofilm formation,inhibit oral connective tissue and bone tissue destruction,and show anti-inflammatory and antioxidant properties in periodontitis.Additionally,HRW can alleviate periodontal tissue damage by inhibiting oxidative stress and up-regulating the expression of antioxidant enzymes,such as glutathione peroxidase and superoxide dismutase.HRW exerts anti-inflammatory effects by regulating the nuclear factor erythroid 2-related factor 2 and mitogen-activated protein kinase pathways,which are closely associated with inflammation.Additionally,HRW inhibits the expression of inflammatory cytokines,such as interleukins,inhibits the growth and proliferation of bacterial plaque biofilms,and down-regulates glycosyltransferases and glucanbinding proteins to prevent bacterial adhesion and subsequent development of periodontitis.Furthermore,HRW has a positive effect on the expression of various cell growth factors,α-smooth muscle actin,and type Ⅰ collagen,which promotes wound healing.Current clinical studies have demonstrated the biological safety of HRW(to a certain extent)and reported no adverse reactions.However,most studies on HRW in oral diseases are preclinical in vivo and in vitro studies.Therefore,further clinical studies are required to validate the therapeutic significance and optimal therapeutic regimen of HRW in human periodontitis.This article aims to review the therapeutic role and the underlying mechanisms of HRW in periodontitis.
作者
刘福双
卫晓萱
周剑鹏
王骏
LIU Fushuang;WEI Xiaoxuan;ZHOU Jianpeng;WANG Jun(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Periodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《口腔疾病防治》
2025年第1期68-74,共7页
Journal of Prevention and Treatment for Stomatological Diseases
基金
四川省重点研发计划项目(2023YFS0032)。
关键词
分子氢
富氢水
牙周炎
菌斑生物膜
伤口愈合
氧化性应激
炎症
细胞生长因子
抗菌
molecular hydrogen
hydrogen-rich water
periodontitis
dental plaque biofilm
wound healing
oxidative stress
inflammation
cell growth factors
anti-bacteria
