摘要
基因编码的靶向蛋白降解是一种以遗传信息为基础的降解分子在细胞内表达编码的治疗方法,已经在许多癌症疾病的“不可药用”蛋白的降解中发挥着极为重要的作用。综述了GE-TPD近年来的一些进展及其E3连接酶和目标蛋白结合域的设计和模块选择;并展望了GE-TPD个性化定制的前景和挑战。
Genetically encoded targeted protein degradation(GE-TPD)is a therapeutic approach that leverages genetic information to express degrading molecules within cells.It currently plays a crucial role in the degradation of previously“undruggable”proteins associated with various cancers and other diseases.This review summarizes recent advancements in GE-TPD,including the design and selection of E3 ligases and target protein binding domains,as well as module selection,and explores the prospects and challenges of its personalized applications.
作者
吴雨晴
黄惠珍
闫大琦
胡君
WU Yuqing;HUANG Huizhen;YAN Daqi;HU Jun(College of Life Sciences,Fujian Agriculture and Forestry University,Fuzhou 350002,China;School of Future Technology,Fujian Agriculture and Forestry University,Fuzhou 350002,China)
出处
《福建师范大学学报(自然科学版)》
北大核心
2025年第1期102-108,共7页
Journal of Fujian Normal University:Natural Science Edition
基金
国家自然科学基金青年项目(32201738)
福建省自然科学基金面上项目(2023J01451)。
