摘要
目的 了解鼻咽癌患者周围血单核细胞 (PBMC)的钙、镁、铜、锌、铁等 5种金属元素含量及其增殖反应 ,探讨PBMC中金属元素和细胞免疫在鼻咽癌发生、发展之间的关系。方法 采用日本岛津AA670型原子吸收光谱仪火焰法测定金属元素 ,以3H TdR掺入法检测PBMC对ConA的增殖反应。结果 53例鼻咽癌患者PBMC与正常对照组比较 ,铜含量升高 (P <0 0 1 ) ,锌含量降低 (P <0 0 1 ) ,PBMC增殖反应指数下降 (P <0 0 1 )。结论 提示鼻咽癌患者PBMC的铜含量增高 ,而锌含量和淋巴细胞增殖反应指数降低 ,与鼻咽癌的发生。
Objective The econtents of calcium, magnesium,copper, Zinc, iron and lymphocyte proliferation in the nasopharygneel carcinomas and normal subjects of peripheral blood mononuclear cell from 53 cases was determined.Methods Metal elements and lymphocyte proliferation were detected in patients with atomic absorption spectrometer and methods of 3H TdR. Results It was significantly higher level of copper, significantly lower level of zinc and lymphocyte proliferation in the patients with nasopharyngeal carcinomas than in those of normal subjects.Conclusion The results of correlative analysis showed that there was a significant correlationship between the is levels of copper and zinc and significantly index of lymphocyte proliferation in the nasopharyngeal carcinoma.
出处
《中国实验诊断学》
2002年第6期372-374,共3页
Chinese Journal of Laboratory Diagnosis
基金
广东省科委重大攻关项目编号:2KMO4 30 75
关键词
鼻咽癌
免疫效应
周围血单核细胞
金属元素
淋巴细胞增殖
nasopharyngeal neoplasms
peripheral blood monouclear cell
metal element
lymphocyte proliferation
