摘要
目的 探讨甲状腺功能亢进症 (简称甲亢 ) 1 31 I治疗后早发甲状腺功能减退症 (简称甲低 )的相关因素。方法 2 4 0例甲亢患者行1 31 I治疗 ,观察各影响因素并记录完整 ,1年内随访 ,对可能与早发甲低有关的多个因素用向前逐步筛选变量法行Logistic回归判别分析 ,对各研究指标行单因素 χ2 检验。结果 ①多因素分析结果示患者年龄、甲状腺质量、发病情况、吸碘率曲线形态、给予患者每克甲状腺组织的1 31 I剂量等 5个因素与早发甲低发生相关 ;单因素分析结果示甲状腺质量、最高吸碘率、甲亢患者所服1 31 I剂量等 3个因素与早发甲低相关。②经检验 ,Logistic回归方程有统计学意义。③对研究对象行Logistic回归判别即回代检验 ,早发甲低发生与不发生的准确性分别为 6 4 0 8%、78.83% ,总准确性为 72 .5 0 %。结论 分类估算和调整给药剂量是治愈甲亢、降低早发甲低发生率的关键 ;加强随访和必要时补充甲状腺激素是减少早发甲低发展成永久性甲低的重要措施。
ObjectiveTo explore the factors correlative with the early hypothyroidism after 131I therapy for Graves' hyperthyroidism so as to cure it and decrease the early hypothyroidism occurring and prevent it from becoming irreversible hypothyroidism. MethodsLogistic regression discriminatory analysis by introducing multiple factors from group data and forward stepwise selection of 11 independent variables of 240 hyperthyroidism patients from clinical data and 1 dependent variable from follow-up data after 131I therapy was conducted. Univariate analysis of each observed factor was performed, too. THResults①The results of multivariate analysis showed that the age of patients, the weight of thyroid, the suffering situation, the curve of 131I absorption rate and the giving 131I dosage/g thyroid tissue were correlated to early hypothyroidism. The results of univariate analysis showed that the weight of thyroid, the highest absorption of 131I, the total treatment dosage of 131I were correlated to early hypothyroidism. ②The logistic regression equation was statistically significant. ③The positive and negative predicting accuracy of the early hypothyroidism occurring was 64.08%, 78.83%, respectively, the overall predicting accuracy was 72.50%. ConclusionsThe dosage of 131The discriminatory analysis about factors correlative with the early hypothyroidism after 131I therapy for hyperthyroidism$$$$ XIONG Lingjing, LIANG Changhua, DENG Haoyu, et al. Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China AbstractObjectiveTo explore the factors correlative with the early hypothyroidism after 131I therapy for Graves' hyperthyroidism so as to cure it and decrease the early hypothyroidism occurring and prevent it from becoming irreversible hypothyroidism. MethodsLogistic regression discriminatory analysis by introducing multiple factors from group data and forward stepwise selection of 11 independent variables of 240 hyperthyroidism patients from clinical data and 1 dependent variable from follow-up data after 131I therapy was conducted. Univariate analysis of each observed factor was performed, too. THResults①The results of multivariate analysis showed that the age of patients, the weight of thyroid, the suffering situation, the curve of 131I absorption rate and the giving 131I dosage/g thyroid tissue were correlated to early hypothyroidism. The results of univariate analysis showed that the weight of thyroid, the highest absorption of 131I, the total treatment dosage of 131I were correlated to early hypothyroidism. ②The logistic regression equation was statistically significant. ③The positive and negative predicting accuracy of the early hypothyroidism occurring was 64.08%, 78.83%, respectively, the overall predicting accuracy was 72.50%. ConclusionsThe dosage of 131[I for treatment of hyperthyroid is the key factor according to the five correlative factors which are relating to the early hypothyroidism and the discriminatory classification. Enhanced follow-up and in time supplement of thyroid hormone are important measures for preventing the early hypothyroidism from becoming irreversible hypothyroidism.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2002年第6期354-355,共2页
Chinese Journal of Nuclear Medicine
