摘要
本文报告哌拉西林、哌拉西林／他唑巴坦（８：１、４：１）和替卡西林／克拉维酸（１５：１）对３９株革兰阴性杆菌所产β－内酰胺酶稳定性的比较。以生物法测定酶对抗生素的相对水解率、抑酶保护率。结果表明：β－内酰胺酶对哌拉西林／他唑巴坦（８：１）的相对水解率明显低于单独使用哌拉西林（Ｐ＜０．０１）且优于替卡西林／克拉维酸（Ｐ＜０．０５）。当哌拉西林／他唑巴坦为４：１时，相对水解率与８：１相比又有非常显著降低（Ｐ＜０．０１），４：１明显优于８：１。说明他唑巴坦起到了增强哌拉西林对β－内酰胺酶的稳定性和抑酶保护的作用。
The stability of piperacillin, piperacillin/tazobactam (8:1、4:1)and ticarcillin/clavulanic acid to preparation of crude β-lactamases due to Gram-negative bacilli from 39 strains were determined by bioassay method. The results indicated that relative hydrolysis rate of piperacillin/tazobactam(8:1) was lower than piperacillin and ticarcillin/clavulanic acid .The combination ratio 4:1(piperacillin/tazobactam)of the two compounds showed significantly more stable to β-lactamases produced by Gram-negative bacilli than other combination ratio to the same enzymes.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1998年第2期113-120,共8页
The Chinese Journal of Clinical Pharmacology
