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胃癌DNA甲基化谱研究进展 被引量：4

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摘要 肿瘤的发生与多基因的异常有关,其中,DNA甲基化作为基因表达调控的一种方式,其甲基化状态的改变与基因的异常表达相关.胃癌的发生亦系多因素、多阶段、多基因异常累积的过程.本文就与胃癌有关的肿瘤抑制基因(p14ARF、p16INK4a、APC、pS2、p15INK4b和RASSF1等)、DNA修复基因(MGMT和hMLH1)和其他与肿瘤转移和侵袭有关的基因(CDH1和TIMP-3)的CpG岛甲基化情况作一综述,说明了胃癌的发生与DNA甲基化的关系,揭示了胃癌的形成与DNA甲基化有一定的关系,探讨利用基因甲基化的检测作为胃癌早期诊断的生物学标记的可能性.
作者 张晓兵 刘泽军
机构地区 中国人民解放军第三军医大学附属西南医院检验科
出处 《世界华人消化杂志》 CAS 2002年第12期1454-1457,共4页 World Chinese Journal of Digestology
关键词 胃癌 DNA甲基化谱 研究进展 基因表达调控
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献49

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二级参考文献10

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共引文献4

同被引文献47

  • 1Li Hua Liu1,Wen Hua Xiao2,Wei Wen Liu3 1Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China (now working in Department of Gastroenterology, General Hospital of PLA, Lanzhou 730050, Gansu Province, China)2Department of Oncology3Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.Effect of 5-Aza-2'-deoxycytidine on the P16 tumor suppressor gene in hepatocellular carcinoma cell line HepG2[J].World Journal of Gastroenterology,2001,7(1):131-135. 被引量：21
  • 2Jun Cui,Dong Hua Yang,Xiang Jun Bi,Zi Rong Fan Department of Gastroenterology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, Guangdong Province, China.Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology[J].World Journal of Gastroenterology,2001,7(1):136-139. 被引量：16
  • 3An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book..Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer[J].World Journal of Gastroenterology,2001,7(3):403-406. 被引量：92
  • 4Jing Yi~1 Zhi-Wei Wang~1 Hui Cang~1 Yu-Ying Chen~1 Ren Zhao~2 Bao-Ming Yu~2 Xue-Ming Tang~1 1 Department of Cell Biology,2 Department of Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China.p16 gene methylation in colorectal cancers associated with Duke's staging[J].World Journal of Gastroenterology,2001,7(5):722-725. 被引量：21
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  • 10Sun W, Zaboli D, Wang H, et al. Detection of TIMP3 promoter hypermethylation in salivary rinse as an independent predictor of local recurrence-free survival in head and neck cancer. Clin Cancer Res, 2012, 18:1082-1091.

引证文献4

二级引证文献12

世界华人消化杂志
2002年 第12期

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