摘要
自噬是维持细胞存活、分化、生长和稳态所必须的一种溶酶体降解途径(Levine and Kroemer,2008)。最近的大量研究证实自噬与多种肿瘤细胞的恶性转化和肿瘤细胞的生长有关。哺乳动物雷帕霉素靶蛋白(m TOR)和自噬相关基因Beclin1与细胞自噬关系密切,其可通过调节细胞自噬活性而在肿瘤的发生发展过程中发挥重要的作用。目前,有关肿瘤细胞自噬性死亡的研究受到越来越多人的关注,它很可能成为肿瘤治疗的新靶点。因此,深入研究m TOR、Beclin1在调控自噬过程中与肿瘤的发生发展关系可能对临床上有关肿瘤治疗方面的研究有重要意义。本文现就对自噬通路中m TOR、Beclin1与肿瘤关系的研究进展作一简要概述。
Autophagy is a lysosomal degradation pathway that is essential for cellular survival, differentiation,development and homeostasis(Levine and Kroemer, 2008). Recent studies have demonstrated that autophagy is related to the malignant transformation and growth of cancer cells. Mammalian target of rapamycin(m TOR) and the autophagy related gene Beclin1 have close relationship with autophagy, which can play an important role through regulating the autophagic activity in the genesis and progression of tumor cells. At present, researches about the autophagic death of tumor cells are concerned by more and more people. It is likely to be a new target for tumorous therapy. Therefore, the in-depth researches on the relationship between m TOR, Beclin1 during the process of regulating autophagic activity and tumorous genesis, progression may have important significance for the clinical treatment of tumor. Now, the latest progress of the relationship between m TOR, Beclin1 and tumor in autophagy pathway is briefly summarized.
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2015年第8期1656-1662,共7页
Genomics and Applied Biology
基金
国家自然科学基金项目(81102159
81302378)
广州市教育局广州市属高校"羊城学者"科研项目(12A010D)
广州市教育局广州市属高校科研计划项目(2012C207)共同资助
