摘要
目的 探讨局部亚低温治疗脑出血的临床疗效。方法 将 40例脑出血患者按 1∶1配对随机分为低温组 2 0例和常规组 2 0例。常规组给予脱水药抗高血压药等 ,低温组在常规组治疗的基础上以医用可控式半导体脑保护制冷仪给予局部亚低温治疗 48h。观察两组间脑水肿量和神经功能缺损的差别。结果 入院时两组之间脑水肿量、欧洲卒中评分比较差异均无显著意义 (P >0 0 5 ) ;治疗 1周、2周时脑水肿量低温组为 17 4ml± 6 2ml和 13 1ml± 5 8ml,对照组为 33 8ml± 16 0ml和2 2 4ml± 12 2ml,两组之间脑水肿量比较差异均有显著意义 (P <0 0 5 ) ;治疗 1周、2周时欧洲卒中评分低温组为 6 2 10± 10 84分和 70 3± 10 7分 ,对照组为 5 2 8± 10 9分和 6 0 5± 10 9分 ,两组欧洲卒中评分之间差异均有显著意义 (P <0 0 5 ) ;应用局部亚低温治疗的患者均无不良反应。结论 局部亚低温结合常规治疗对脑出血患者具有明显脑保护作用 ,使用上安全、可靠。
Objective To observe the effect of local mild hypothermia on treatment of acute intracerebral hemorrhage. Methods Forty patients with acute intracerebral hemorrhage were matched according to age and state of illness at a ratio of one to one and then randomly divided into two groups of 20 patients: routine group (dehydrant, antihypertensive agent, etc were given) and hypothermia group (in addition to the general treatment, controllable semiconductor brain-protecting freezer was used to produce local hyperthermia at temperature of 6 ℃ for 48 hours). Immediately after admission and one week and 2 weeks after treatment cranium CT was conducted and the volume of cerebral edema was calculated by Tada′s formula. Results There was no significant difference in the volume of edema and scores according to European Stroke Scale between the two groups at admission (P>0.05). The volumes of edema one week and 2 weeks after therapy were 17.4±6.2 and 13.1±5.8 milliliter respectively in hypothermia group, both significantly lower than those in the routine group (33.8±16.0 and 22.4±12.2 milliliter respectively, P<0.05). The scores according to European Stroke Scale one week and 2 weeks after therapy were 62.1±10.8 and 70.3±10.7 in hypothermia group, both significantly higher than those in the routine group (52.8±10.9 and 60.5±10.9 respectively, P<0.05). No side effect caused by local hyperthermia was observed during the therapy. Conclusion A safe and reliable treatment, local mild hypothermia combined with routine therapy is effective in protecting the brain of patients with intracerebral hemorrhage.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2002年第23期1622-1624,共3页
National Medical Journal of China
关键词
局部亚低温
治疗
急性脑出血
临床研究
Local mild hypothermia
Cerebral hemorrhage
Hypothermia, induced
