摘要
目的:探讨开郁清胃颗粒对糖尿病大鼠血糖及胰岛素敏感性的影响。方法:38只Wister大鼠随机分成正常对照组(n=10)、造模组(n=28),造模组以链脲佐菌素(60mg/kg)造模。成模的22只大鼠随机分成模型组(n=11)和开郁清胃颗粒组(n=11),并开始灌胃给药。治疗10天、20天时各测非空腹血糖一次。实验第21天开始分批禁食20～24小时,10％水合氯醛麻醉,右颈静脉及左颈动脉插管,取血测空腹血糖及基础胰岛素,然后进行正糖钳实验测定葡萄糖输注率,所有大鼠血糖皆稳定在4.3±0.2mmol/L。结束时颈动脉取血测血脂和胰岛素。结果:模型组的基础胰岛素、葡萄糖输注率皆明显低于正常对照组(P<0.05和P<0.01)。开郁清胃颗粒组10天的非空腹血糖,20天的非空腹血糖、空腹血糖、甘油三酯皆显著低于模型组(P<0.01),而葡萄糖输注率显著升高(P<0.01)。结论:开郁清胃颗粒可以降低糖尿病大鼠的血糖,其机理可能与提高糖尿病大鼠的胰岛素敏感性有关。
Objective: To evaluate the efficacy of granules of dispersing - stasis and clearing - stomach - heat on plasma glucose and insulin sensitivity in streptozocin - induced diabetic rats. Methods: 38 male Wisters were randomized to normai control group, streptozocin diabetic group and diabetic group treated with above - noted granules. 20 days lat-er, Ievels of plasma glucose and insulin as well as insulin - induced glucose infusion rate ( GIR) by means of the glucose clamp technique were measured in rats of each group. Results: The STZ - induced rats without treatment had higher plasma glucose level than control animals (p < 0. 01), while their plasma insulin values and GIR were lower than the control animals (p< 0.05 and p < 0.01 respectively) . Plasma glucose, triglyceride and GIR for above granules group vvere significantly lower or higher than the untreated diabetic group after treatment (P < 0.01) , while plasma insulin Ievels vvere unaffected by treatment of above granules ( P > 0.05) . Conclusion: Treatment of above - mentioned granules can decrease the plasma glucose Ievels in STZ - induced diabetic rats, and this effect may be partly achieved by increas-ing the insulin action in the experimental diabetic rats.
出处
《中国医药学报》
CSCD
2002年第10期595-597,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
