摘要
本文对10例正常妇女和28例高泌乳素(PRL)血症妇女用口服奋乃静作垂体PRL兴奋试验。结果显示:正常妇女PRL最大反应值出现时间大都在4(1/2)小时,最大反应比值均大于3。垂体腺瘤组最大反应比值显著低于功能性高PRL组,两者比值部分重迭;有PRL基值大者奋乃静兴奋试验(PST)反应小的关系。提示PST对高PRL血症中垂体腺瘤的诊断有一定的筛选价值。本文对高PRL血症患者对PST不同反应的可能原因进行了探讨。
To evaluate the use of perphenazine stimulating test (PST) in thedifferetial diagnosis between functional hyperprolactinemia and pituitaryprolactin-secreting microadenoma, perphenazine was taken orally by 10normal women (as control) and 28 hyperprolactinemic women (including 11cases of functional hyperprolatinemia and 17 of pituitary prolactin-secreting adenoma). In most control serum prolactin reached a maximallevel at 4(1/2) hours following perphenazine administration. The maximalprolactin levels were at least 3 times the basal level. The mean ratio ofmaximal prolactin level to basal level in the group of functionalhyperprolactinemia was 3.04±2.87 significantly higher than that inpituitary adenoma group. The PST has therefore certain value in distin-guishing the prolactinoma from functional hyperprolactinemia. Moreover,it was observed that a patient with high basal prolactin level has usuallya low response to perphenazine, hence a case of hyperprolactinemia withboth the low basal prolactin level and the blunted response to perphen-azine is probably a patient with prolactinoma.
关键词
高泌乳素血症
诊断
羟哌氯丙嗪
prolactin
hyperprolactinemia
pituitary adenoma
perphenazine
