摘要
本工作以分期门脉阻断法制备大鼠肝前型门脉高压模型,并以正常大鼠为对照就模型动物的一般情况、门静脉压变化、肝组织学变化等情况进行了动态观察。结果表明分期门脉阻断法制备大鼠门脉高压模型具有方法简单、制备周期短、诱发门脉高压成功率高、动物死亡率低等优点,适用于门脉高压症各领域的研究,值得推广。
Prehepatic portal hypertensive rat model was established by the methodof staged portal vein ligation. Changes of general condition, portal veinpressure and hepatic histology of these animals were opserved dynami-cally. Results indicate that it's a simple method with high successfulrate, short preducing period and low animal mortality. Models made bythis method are suitable for most aims of portal hypertension study,therefore, it is deserved to spread.
关键词
门脉高血压
大鼠
动物模型
portal hypertension
rat
model research
