摘要
目的:评价异丙酚复合芬太尼静脉麻醉时,机体对伤害性应激反应。方法:40例颌面部肿瘤病人,随机分为异丙酚静脉麻醉组20例(微泵持续输入异丙酚加芬太尼)和异氟醚吸入麻醉组(吸入异氟醚1.5％-2％)。在麻醉诱导前,插管后1分钟,切皮后1分钟,手术探查时和病变器官切除时测定血浆肾素活性(PRA)、血管紧张素Ⅱ(AⅡ)、醛固酮(ALD)和血液动力学变化。结果:异丙酚静脉麻醉组与异氟醚麻醉组在各测定时点所测肾素、血管紧张素Ⅱ、醛固酮水平、血流动力学两组比较差异无显著性(P>O.05)。结论:异丙酚加芬太尼静脉麻醉对机体的应激反应与异氟醚吸入麻醉的结果相似,均能较好地抑制机体对创伤性刺激的应激反应。
Objective:To evaluate stress reaction of human to injury stimulation during total intravenous anesthesia with propofol and fentanyl. Methods: Forty AsA grade Ⅰ - Ⅱ operative patients with maxillofacial tumeur were randomly divided into propofol - fentanyl intravenous anesthesia group by propofol of 8- 12mg.kg -1h-1 and fentanyl of 2μg.kg -1h-1 infused continously with computer pump and isoflurane inhalation group by inhaling isoflurane of 1. 5% -2. 0% . The plasma rein(PR) , angiotensin Ⅱ (A Ⅱ ) aldosterone(ALD) levels and hemodynamics were measured at pre- induction, 1 min ofter intubation, 1 min after incision, operative explasion and ill organ resection respectively. Results: The levels of PR, A Ⅱ and ALD between both groups were no singnificantly different(P> 0.05) at varions mesurement time. The values of hemodynamics were no difference between both groups(P > 0. 05) . Conclusion: The stress reaction of human to injury stimulation is inhibited effectively by propofol - fentanyl intraveous anesthesia.
出处
《现代医药卫生》
2002年第12期1063-1064,共2页
Journal of Modern Medicine & Health
