摘要
癌症病人常常发生骨转移 ,尤其是乳腺癌和前列腺癌。癌细胞分泌大量的旁分泌因子 ,刺激破骨细胞 ,导致骨质溶解。双膦酸盐是正常的和病理的骨溶解强力抑制剂 ,优先作用于骨形成和骨吸收的活跃位置。临床研究表明 :患有乳腺癌和多发性骨髓瘤的病人 ,长期服用双膦酸盐 ,可预防及减少恶性肿瘤引起的骨骼并发症 ,缓解疼痛 ,提高生命质量。目前 ,双膦酸盐已是恶性肿瘤引起的高钙血症的标准治疗药物。双膦酸盐具有 P- C- P的骨架结构 ,中间碳原子连接的取代基的结构决定着其药理性质。含有氮原子或氨基的双膦酸盐目前是抗吸收能力最强的双膦酸盐。
Bone metastases commonly occur in cancer patients, most frequently in patients with breast and prostatic cancers. Cancer cells secrete a number of paracrine factors that stimulate osteocyte function, resulting in osteolysis. Bisphosphonates are potent inhibitors of both normal and pathologic osteolysis, localizing preferentially to sites of active bone formation and resorption. Clinical studies have shown that long term bisphosphonate treatment in patients with breast cancer and multiple myeloma can decrease and prevent skeletal complications of malignancy, relieve pain, and improve quality of life. Currently, bisphosphonates are the standard treatment for tumor induced hypercalcemia. Bisphosphonates are characterized by a phosphorus-carbon-phosphorus backbond, the variance in side chain structure that are positioned at the central carbon atom of this backbone dictates the difference in the relative antiresorptive potencies. Bisphosphonates with nitrogen containing or aminobisphosphonates are the most potent members of the family.
出处
《天津药学》
2002年第5期8-11,共4页
Tianjin Pharmacy
基金
天津市卫生局科技基金计划项目 (W99KY0 43)
关键词
双膦酸盐
治疗
肿瘤骨转移
Bisphosphonates, bone metastasis, complications
