摘要
目的 探讨乙型肝炎病毒前S1蛋白与乙型肝炎病毒复制的关系及其在临床上的应用。方法 通过对 10 1例乙型肝炎患者血清进行“两对半”、HBV DNA和前S1蛋白的检测分析。结果 10 1例HBsAg阳性与HBV DNA同时阳性的血清 ,Presl检出率为 94 .1% ,HBeAg/Ab的阳性率分别为 5 8.4 %和 30 .7% ;78例preS1Ab阳性血清中 ,抗HBs阳性率为 4 7.4 % ,抗HBe阳性率为 2 8.2 %。结论 乙型肝炎病毒前S1蛋白表达主要在HBVDNA复制期 。
Objective To compare the relationship between the expression of pre S1 protein and HBV replication and its clinical application. Methods Sera of 101 HBsAg ,HBV DNA and pre S1 protein were analyzed. Results The positive rate for pre S1 antigen was 94.5%, the positive rate for HBsAg and HBsAb was 58.7%, 30.8% respectively; in sera of 78 preS1 antibody positive patients, the positive rate for HBsAb was 48.4%, that of HBeAb was 28.2%. Conclusion All these findings suggest that the pre S1 protein might be mainly expressed at the HBV replication phase, thus, to some extent, the detection of pre S1 protein might complement HBe system and HBVDNA clinical routine.
出处
《重庆医学》
CAS
CSCD
2002年第12期1171-1172,共2页
Chongqing medicine
