摘要
即时检验是指在采样现场进行并能够快速得到检验结果的一类检测方法。因具有响应速度快、灵敏度高、特异性好、操作简便的优势,尤其适用于紧急救治环境或者医疗资源匮乏的地区。近年来在主动健康的背景下,即时检验朝着小型化、集成化、智能化方向发展,基于可穿戴的即时检验技术逐步成为未来个性化预警的潜在方案。本文综述了即时检验的发展历程,阐述了其从单时相检测到个性化可穿戴监测的特征变化,强调了即时检验的技术难点从提高检测灵敏度到实现智能监测、预警的演变。针对临床对个体化健康管理需求的增加,本文提出了“健康全息检验”的概念,并探讨了其未来发展的方向以及实施过程中的挑战与解决方案,旨在为全民健康提供新思路和理念,进而促进即时检验领域的发展。
Point-of-care testing(POCT)refers to a type of diagnostic method that provides rapid test results at the sampling site.It has advantages such as fast response time,high sensitivity,good specificity,and ease of operation,making it particularly suitable for areas with limited medical infrastructure or scarce resources.In recent years,under the context of proactive health,POCT has been evolving towards miniaturization,integration,and intelligence.Based on wearable POCT,it is gradually becoming a potential solution for future personalized diagnostics.This article reviews the development of POCT,elaborating on its transition from single-phase testing to personalized wearable monitoring,and emphasizes the evolution of the technical challenges from improving detection sensitivity to achieving intelligent monitoring and early warning.In response to the increasing clinical demand for personalized health management,we introduce a new concept of“Omni-Health Testing”and discuss its future development directions.Finally,the article analyzes the challenges and solutions during its implementation process,aiming to provide new concepts and technologies for public health and promote the development of instant testing.
作者
邱晓沛
胡孝林
张洪
顾玮
王永忠
罗阳
Xiaopei Qiu;Xiaolin Hu;Hong Zhang;Wei Gu;Yongzhong Wang;Yang Luo(Department of Laboratory Medicine,Chongqing General Hospital,Chongqing University,Chongqing 400013;Center of Smart Laboratory and Molecular Medicine,School of Medicine,Chongqing University,Chongqing 400030;College of Bioengineering,Chongqing University,Chongqing 400044)
出处
《中国科学基金》
CSSCI
CSCD
北大核心
2024年第6期1033-1042,共10页
Bulletin of National Natural Science Foundation of China
基金
国家自然科学基金项目(82125022,82202633,82241059)
国家重点研发计划(2022YFC2009600,2022YFC2009603)的资助。
关键词
即时检验
可穿戴
疾病预警
健康全息检验
全生命周期
point-of-care testing
wearable technology
disease prediction
omni-health testing
life cycle
