摘要
微小RNA(miRNA)的发现标志着分子生物学的新阶段,2024年诺贝尔生理学或医学奖授予维克托·安布罗斯和加里·鲁夫昆,以表彰其对miRNA的开创性研究。目前,非编码RNA研究已成为后基因组时代生命科学的前沿,正在引领现阶段生命科学研究的发展。我国在miRNA领域的研究与国际同步切入,已取得重要突破,促使我国在非编码RNA研究领域的国际地位逐渐上升。本文介绍了首次发现miRNA的研究基本背景,分析了该研究获得诺贝尔奖的深层原因及其对人类社会认知和推动科技进步的重大意义,重点梳理了国内在该领域的研究成果、现状以及差距,探讨了未来发展趋势以及研究方向。
The discovery of microRNAs(miRNAs)marks a new phase in molecular biology.The 2024 Nobel Prize in Physiology or Medicine was awarded to Victor Ambros and Gary Ruvkun in recognition of their pioneering research on miRNAs.Currently,non-coding RNA research has become the forefront of life sciences in the post-genomic era,leading the development of contemporary life science research.China has made significant breakthroughs in the field of miRNA,aligning its research efforts with international advancements.This article presents the fundamental background of the initial discovery of miRNAs,analyzes the deeper reasons for the Nobel Prize recognition,and highlights the significant impact of this research on human understanding and technological progress.Additionally,it focuses on domestic research achievements,current status,and gaps in this field,while exploring future development trends and research directions.
作者
陈雪曼
宋尔卫
Xueman Chen;Erwei Song(Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120)
出处
《中国科学基金》
CSSCI
CSCD
北大核心
2024年第6期997-1000,共4页
Bulletin of National Natural Science Foundation of China
基金
国家自然科学基金项目(82488101,82330056)的资助。
