摘要
目的:探讨外周血炎症相关指标联合癌胚抗原(CEA)诊断结直肠癌的价值。方法:选取2023年4月至2024年2月我院收治的78例结直肠癌患者,以及同期收治的78例结直肠息肉患者进行研究。比较结直肠癌和结直肠息肉患者外周血血小板与淋巴细胞比值(PLR)、中性粒细胞-淋巴细胞比值(NLR)、单核细胞-淋巴细胞比值(MLR)和淋巴细胞-C反应蛋白比值(LCR)及CEA水平;通过二元Logistic回归分析影响结直肠癌发生的因素;通过ROC曲线分析外周血各炎症相关指标、CEA及联合诊断结直肠癌的价值;分析结直肠癌外周血炎症相关指标与CEA的相关性。结果:结直肠癌组PLR、NLR、MLR及CEA水平均高于结直肠息肉组,LCR水平低于结直肠息肉组(P<0.05)。二元Logistic回归分析显示,PLR、NLR、MLR、LCR及CEA均是结直肠癌发生的独立影响因素(P<0.05)。ROC曲线显示,PLR、NLR、MLR、LCR及CEA诊断结直肠癌的AUC分别为0.746、0.768、0.653、0.750和0.774,均具有一定准确性。外周血炎症相关指标PLR、NLR、MLR、LCR 4项联合,及外周血炎症相关指标+CEA 5项联合诊断结直肠癌的AUC分别为0.900和0.910,敏感度分别为74.4%和73.1%,特异性分别为91.0%和98.7%。Pearson相关性分析显示,结直肠癌患者外周血PLR、NLR、MLR与CEA水平呈正相关(P<0.05),LCR与CEA水平呈负相关(P<0.05)。结论:外周血炎症相关指标联合CEA诊断结直肠癌具有一定价值,且外周血炎症相关指标与CEA相关。
Objective To evaluate the diagnostic value of peripheral blood inflammatory indicators combined with carcinoembryonic antigen(CEA)in colorectal cancer(CRC).Methods Total 78patients with CRC admitted to our hospital from April 2023to February 2024and 78patients with colorectal polyps(CRP)admitted during the same period were studied.The levels of platelet to lymphocyte ratio(PLR),neutrophils to lymphocyte ratio(NLR),monocytes to lymphocyte ratio(MLR),lymphocyte to C-reactive protein ratio(LCR)and CEA in peripheral blood of patients with CRC and CRP were detected and compared.The factors influencing the incidence of CRC were analyzed by bivariate logistic regression analysis.The value of peripheral blood inflammatory indicators,CEA and combined diagnosis of CRC was analyzed by ROC curve.The correlation between peripheral blood inflammatory indicators and CEA was analyzed.Results The levels of PLR,NLR,MLR and CEA in the CRC group were higher than those in the CRP group,and the LCR level was lower than that in the CRP group(P<0.05).Bivariate logistic regression analysis showed that PLR,NLR,MLR,LCR and CEA were independent influencing factors of CRC(P<0.05).ROC curve showed that the AUC of PLR,NLR,MLR,LCR and CEA in the diagnosis of CRC were 0.746,0.768,0.653,0.750and 0.774,respectively,with certain accuracy.The AUC,sensitivity,specificity of the 4combined peripheral blood inflammatory indicators of PLR,NLR,MLR and LCR,and the 5combined indicators of PLR,NLR,MLR,LCR and CEA in the diagnosis of CRC were 0.900and 0.910,74.4%and 73.1%,91.0%and 98.7%,respectively.Pearson correlation analysis showed that PLR,NLR and MLR in peripheral blood of CRC were positively correlated with CEA level(P<0.05),while LCR was negatively correlated with CEA level(P<0.05).Conclusion Peripheral blood inflammatory indicators combined with CEA have certain value in the diagnosis of CRC,and the peripheral blood inflammatory indicators are correlated with CEA.
作者
张建
买春阳
闫振宇
苏博
陈晴
ZHANG Jian;MAI Chun-yang;YAN Zhen-yu;SU Bo;CHEN Qing(Department of Pathology,Nanyang Central Hospital,Nanyang,Henan 473000;Department of Clinical Laboratory,Nanyang Central Hospital,Nanyang,Henan 473000)
出处
《中国肛肠病杂志》
2024年第11期17-20,共4页
Chinese Journal of Coloproctology
