摘要
目的探讨血清血管内皮生长因子(VEGF)、血管性血友病因子(vWF)及凝血指标与分化型甲状腺癌(DTC)预后的相关性。方法选择2021年1月至2022年12月山西省肿瘤医院头颈外科收治的甲状腺癌(TC)患者136例为TC组,同期确诊的甲状腺良性结节患者80例为对照组,比较两组VEGF、vWF及凝血指标;采用Kaplan-Meier法计算患者无瘤生存期。结果与对照组比较,TC组VEGF、vWF、凝血酶时间(TT)、纤维蛋白原(Fbg)更高,凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)水平更低(P<0.001);与年龄<55岁患者比较,年龄≥55岁患者VEGF、vWF、TT、Fbg水平更高,PT、APTT水平更低(P<0.001);与乳头状癌患者比较,滤泡状癌患者VEGF、vWF、TT、Fbg水平更高,PT、APTT水平更低(P<0.001);与TNM分期I~II期患者比较,TNM分期III~IV期患者VEGF、vWF、TT、Fbg水平更高,PT、APTT水平更低(P<0.001);与无淋巴结转移患者比较,有淋巴结转移患者VEGF、vWF、TT、Fbg水平更高,PT、APTT水平更低(P<0.001);与肿瘤大小<2 cm患者比较,肿瘤≥2 cm患者VEGF、vWF水平更高(P<0.001);生存曲线分析显示,高VEGF组、高vWF组、高TT组、高Fbg组无瘤生存期短于低VEGF组、低vWF组、低TT组、低Fbg组(Log-rank=9.149、8.856、4.683、5.867,P<0.001)。结论TC患者VEGF、vWF及凝血指标与临床病理特征存在相关,且有助于预测术后无瘤生存状况。
ObjectiveTo investigate the correlation between serum vascular endothelial growth factor(VEGF),von Willebrand factor(vWF)and coagulation index and prognosis of differentiated thyroid cancer(TC).Methods136 TC patients admitted in Department of Head and Neck Surgery Shanxi Cancer Hospital from Jan.2021 to Dec.2022 were selected as TC group,and 80 patients with confirmed thyroid benign nodule during the same period were selected as control group.VEGF,vWF and coagulation indexes were compared between the two groups.The tumor free survival was calculated by Kaplan-Meier method.ResultsCompared with the control group,the levels of VEGF,vWF,TT,Fbg in TC group were higher,and the levels of PT,APTT were lower(P<0.001).Compared with patients<55 years old,the levels of VEGF,vWF,TT and Fbg were higher in patients≥55 years old,and the levels of PT and APTT were lower(P<0.001).Compared with papillary carcinoma,the levels of VEGF,vWF,TT and Fbg were higher in follicular carcinoma patients,and the levels of PT and APTT were lower(P<0.001).The levels of VEGF,vWF,TT and Fbg were higher and the levels of PT and APTT were lower in patients with TNM stage III to IV than in patients with TNM stage I to II(P<0.001).Compared with patients without lymph node metastasis,VEGF,vWF,TT,Fbg levels were higher in patients with lymph node metastasis,and PT,APTT levels were lower(P<0.001).Compared with patients with tumor size<2 cm,VEGF and vWF levels were higher in patients with tumor size≥2 cm(P<0.001).Survival curve analysis showed that the tumor free survival of high VEGF,high vWF,high TT and high Fbg groups was shorter than that of low VEGF,low vWF,low TT and low Fbg groups(Log-rank=9.149,8.856,4.683,5.867,P<0.001).ConclusionVEGF,vWF and coagulation indexes in TC patients were correlated with clinicopathological features,and were helpful to predict postoperative tumor-free survival.
作者
丁炜
苗永民
王伟
刘美亚
Ding Wei;Miao Yongmin;Wang Wei;Liu Meiya(Department of Head and Neck Surgery,Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital,Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University,Taiyuan 030013,China;Department of Breast Surgery,Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital,Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University,Taiyuan 030013,China;Department of Breast Surgery,the Second Affiliated Hospital of Shanxi Medical University,Taiyuan 030606,China)
出处
《中华内分泌外科杂志（中英文）》
CAS
2024年第6期835-840,共6页
Chinese Journal of Endocrine Surgery
基金
山西省医师协会医师科研项目(YSXH-QL2023RX004)。
