摘要
全球超过10%的人口受到慢性肾病(chronic kidney disease,CKD)的威胁。大量研究证据表明,低水平的维生素D与CKD的进展和不良预后存在联系。随着研究的深入,维生素D及维生素D受体(vitamin D receptor,VDR)在CKD中的作用越来越受到关注。目前,提高CKD患者维生素D的水平或使用VDR激动剂成为CKD的治疗手段。对维生素D的合成与代谢,VDR的分布、功能与调控,维生素D与CKD之间的联系以及维生素D-VDR轴对CKD的保护机制4个方面进行综述,以期为CKD的疾病预防和治疗提供一定的理论依据及研究思路。
More than 10%of the global population are threatened by chronic kidney disease(CKD).Substantial research suggests that there is a link between low levels of vitamin D and the progression and adverse prognosis of CKD.With the deepening of research,the role of vitamin D and vitamin D receptor(VDR)in CKD has gained increasing attention.Recently,raising vitamin D levels or using VDR agonists in CKD patients has become a therapeutic approach for CKD.This article reviews the synthesis and metabolism of vitamin D,the distribution,function and regulation of VDR,the relationship between vitamin D and CKD,and the protective mechanism of vitamin D-VDR axis on CKD,in order to provide theoretical basis and research ideas for the prevention and treatment of CKD.
作者
孙娟
崔雪扬
王鹤霏
江振洲
黄鑫
SUN Juan;CUI Xueyang;WANG Hefei;JIANG Zhenzhou;HUANG Xin(New Drug Screening and Pharmacodynamics Evaluation Center,State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China)
出处
《药学进展》
CAS
2024年第12期942-950,共9页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金(No.82174072)。
关键词
维生素D
维生素D受体
慢性肾病
vitamin D
vitamin Dreceptor
chronic kidney disease
