摘要
EBV相关性胃癌(EBV-associated gastric cancer,EBVaGC)是一种与EB病毒(Epstein-Barr virus,EBV)相关的胃癌类型,虽然其发病率较低,但具有独特的临床特点.EBVaGC患者多为年轻男性,且初诊时大多为局部晚期,尽管如此,其预后较好.该类型胃癌的肿瘤微环境中常见显著的淋巴细胞浸润,呈现出更“热”的免疫微环境.研究表明,晚期EBVaGC患者对免疫检查点抑制剂的治疗反应优于普通胃癌患者.本文综述了EBVaGC的疾病特征、临床诊治进展及免疫治疗的潜力,旨在为深入探讨该病的免疫微环境、免疫治疗策略及耐药机制提供指导,为临床治疗与前瞻性试验设计提供理论依据,以期推动该领域的进一步研究.
EBV-associated gastric cancer(EBVaGC)is a type of gastric cancer related to the infection of Epstein-Barr virus(EBV),with a low incidence rate.EBVaGC tends to occur in younger patients,male predominance,and is often diagnosed as locally advanced with a good prognosis.The tumor microenvironment of EBVaGC is characterized by significant lymphocyte infiltration,contributing to a more active immune landscape.Patients with advanced EBVaGC have a higher response rate to immune checkpoint inhibitors compared to patients with ordinary gastric cancer.This article reviews the disease characteristics and the treatment progress of EBVaGC.
作者
邱妙珍
徐瑞华
QIU MiaoZhen;XU RuiHua(Department of Medical Oncology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer,Chinese Academy of Medical Sciences,Guangzhou 510060,China)
出处
《中国科学:生命科学》
CSCD
北大核心
2024年第12期2357-2362,共6页
Scientia Sinica(Vitae)
关键词
胃癌
EB病毒
流行病学特征
临床特征
预后
gastric cancer
Epstein-Barr virus
epidemiological characteristics
clinical features
prognosis
