摘要
利用小鸡和小鼠的耳蜗损伤模型,研究了二者在内耳毛细胞再生过程中的差异,并集中论述Notch、Wnt、BMP、FGF和Hh等关键信号通路在毛细胞再生过程中的联合调控作用.结果表明:运用腺病毒载体技术可激活多个信号通路,能够诱导支持细胞从静止状态进入细胞周期进而增殖和分化为新的毛细胞,可在小鼠模型中实现某种程度的毛细胞再生.哺乳动物毛细胞再生能力有限,但仍可通过精确的分子调控策略加以诱导.
Using chicken and mouse cochlear damage models,the study elucidates the differences between the two in the process of inner ear hair cell regeneration,with a focus on the combined regulatory role of key signaling pathways such as Notch,Wnt,BMP,FGF,and Hh during hair cell regeneration.Employing adenoviral vector technology to activate multiple signaling pathways can induce supporting cells to exit quiescence,enter the cell cycle,proliferate,and differentiate into new hair cells,achieving a certain degree of hair cell regeneration in mouse models.These studies indicate that the regenerative capacity of mammalian hair cells is limited but can still be induced through precise molecular regulation strategies.This provides theoretical basis and practical approaches for further development of therapeutic interventions based on signaling pathway manipulation,aimed at promoting the rehabilitation of human sensorineural hearing loss.
作者
张信文
杨思远
白焕菊
江凌玲
曾少举
ZHANG Xin-wen;YANG Si-yuan;BAI Huan-ju;JIANG Ling-ling;ZENG Shao-ju(College of Pharmacy,Hainan Vocational University of Science and Technology,Haikou 571126,China;College of Life Science,Hainan Normal University,Haikou 571158,China;College of Life Sciences,Beijing Normal University,Beijing 100875,China;Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)
出处
《东北师大学报（自然科学版）》
CAS
北大核心
2024年第4期109-114,共6页
Journal of Northeast Normal University(Natural Science Edition)
基金
海南省自然科学基金资助项目(319QN238)
国家自然科学基金资助项目(31860269)。
关键词
毛细胞再生
信号通路
多基因联合调控
鸡
鼠
hair cell regeneration
signaling pathway
multi-gene joint regulation
chicken
mouse
