摘要
Dysregulated or weak immunity is caused by ageing,chemo-radiotherapy,COVID-19,infections,steroids,pol-lutants and toxins.Bioactive foods are required for boosting immunity.In the present study,eight rice(Oryza sativa L.)varieties were selected from the repository of 23,250 Indian germplasm accessions.The immuno-modulatory effects of these rice varieties were assessed in vitro and in vivo.Layacha-rice-methanolic-extract(Larimex)significantly enhanced innate(>20%)and adaptive(>10%)immune responses evinced from higher bacterial phagocytosis by macrophages,increased mitogen-induced T-cell proliferation(11%)and scavenged reactive oxygen species(ROS)(70-80%).Larimex activated transcription factor Nrf2 and its downstream genes NQO1,HO1 and Txnrd1 in immune cells.Larimex significantly improved immune responses(>20%)only in cells from wild type but not Nrf2 knock-out mice indicating its causal role in boosting immunity.Untargeted metabolomics of Layacha rice showed preponderance of metabolic pathways and bioactive compounds,which activate Nrf2 in mammalian cells.Layacha rice can be a suitable food for boosting immunity.
基金
supported by Board of Research in Nuclear Sciences(BRNS,Department of Atomic Energy,Government of Indiaa[55/15/01/2019-BRNS]
Bhabha Atomic Research Centre,Department of Atomic Energy,Government of India
SJ&AT received fellowship from DST-INSPIRE,Government of India.
