摘要
目的:分析帕立骨化醇联合西那卡塞方案治疗甲状旁腺功能亢进患者的效果。方法:选取吉林省人民医院2023年1月—2024年2月收治的60例甲状旁腺功能亢进患者为研究对象,按随机数字表法分为对照组和观察组,各30例。对照组应用西那卡塞治疗,观察组在此基础上联合帕立骨化醇治疗。比较两组甲状旁腺功能、钙磷代谢、成纤维细胞生长因子23(FGF23)及Klotho蛋白水平。结果:治疗后,两组甲状旁腺激素水平、甲状旁腺体积降低,观察组低于对照组(P<0.05);治疗后,两组血钙、血磷水平降低,观察组血磷水平低于对照组(P<0.05);治疗后,两组血钙水平比较,差异无统计学意义(P>0.05);治疗后,两组FGF23水平降低,Klotho蛋白水平升高,观察组优于对照组(P<0.05)。结论:帕立骨化醇联合西那卡塞治疗能够降低甲状旁腺功能亢进患者的甲状旁腺体积、甲状旁腺激素水平,改善钙磷代谢、骨代谢功能。
Objective:To analyze the effect of paricalcitol combined with cinacase in the treatment of hyperparathyroidism.Methods:Sixty patients with hyperparathyroidism admitted to Jilin Provincial People's Hospital from January 2023 to February 2024 were selected as the study objects,and were divided into control group and observation group according to random number table method,with thirty cases in each group.The control group was treated with cinacase,and the observation group was treated with paricalcitol on this basis.Parathyroid function,calcium and phosphorus metabolism,fibroblast growth factor 23(FGF23)and Klotho protein levels were compared between the two groups.Results:After treatment,the level of parathyroid hormone and the volume of parathyroid gland in two groups were decreased,and the observation group was lower than the control group(P<0.05);after treatment,the serum calcium and phosphorus levels were decreased in both groups,and the serum phosphorus level in observation group was lower than that in control group(P<0.05);after treatment,there was no significant difference in blood calcium level between the two groups(P>0.05);after treatment,the level of FGF23 decreased and the level of Klotho protein increased in both groups,and the observation group was better than the control group(P<0.05).Conclusion:Paricalcitol combined with cinacase can reduce parathyroid volume and parathyroid hormone levels in patients with hyperparathyroidism,and improve calcium and phosphorus metabolism and bone metabolism.
作者
王萍萍
桑大华
隋航
王磊
Wang Pingping;Sang Dahua;Sui Hang;Wang Lei(Jilin Provincial People's Hospital,Changchun 130000,Jilin Province,China)
出处
《中外医药研究》
2024年第31期93-95,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
