摘要
肥胖(OB)和2型糖尿病(T2DM)是两种常见的代谢性疾病,与椎间盘退变(IDD)密切相关。OB可能通过增加脊柱的机械应力以及促进白色脂肪组织分泌脂肪因子而导致IDD的发生。T2DM通过影响椎间盘的血液供应和营养,并通过晚期糖基化终末产物(AGEs)诱发炎症反应,加速IDD的病理过程。脂肪细胞分泌多种脂肪因子(IL-6、TNF-α、瘦素、抵抗素和脂联素),可能参与IDD的病理生理过程。AGEs通过激活RAGE受体和NLRP3炎症小体,导致椎间盘细胞凋亡。因此,进一步阐明OB和T2DM在IDD发生和发展中的作用及其机制,将为IDD的诊治及预防提供更多策略。
Obesity(OB)and type 2 diabetes mellitus(T2DM)are two common metabolic diseases that are closely related to intervertebral disc degeneration(IDD).OB may lead to the occurrence of IDD by increasing the spinal mechanical stress and promoting the secretion of adipokines by white adipose tissue.T2DM accelerates the pathological process of IDD by affecting the blood supply and nutrition of the intervertebral disc and evoking in‐flammatory reactions through advanced glycation end products(AGEs).Various adipokines,such as IL-6,TNF-α,leptin,resistin,and adiponectin,are secreted by adipocytes and may participate in the pathophysiology of IDD.In addition,AGEs cause intervertebral disc cell apoptosis by activating RAGE receptors and NLRP3 inflammasome.Therefore,further elucidating the effects and mechanisms of OB and T2DM in the initiation and progression of IDD will provide more strategies for the prevention and treatment of IDD.
作者
秦志琳
江华
QIN Zhilin;JIANG Hua(Health Management Center,Jiangbin Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Department of Spine Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《广西医科大学学报》
CAS
2024年第12期1677-1684,共8页
Journal of Guangxi Medical University
基金
国家自然科学基金资助项目(No.82360438)
广西自然科学基金区域高发疾病研究联合专项资助(No.2024GXNSFDA010043)。
关键词
肥胖
2型糖尿病
代谢性疾病
脂肪因子
椎间盘退变
obesity
type 2 diabetes mellitus
metabolic diseases
adipokines
intervertebral disc degeneration
