摘要
Due to the multiple health benefits associated with the consumption of cannabinoids,there is a current trend on continuing to explore their biological properties.Cannabidiol(CBD)is likely to be the most investigated endocannabinoid from the cannabis plant.Unfortunately,the purification of CBD from its natural source and psychotropic analogue(tetrahydrocannabinol,THC)is timely challenging for the research community based on the similar physiochemical properties of both molecules.This latter fact becomes relevant for the final application of CBD in edibles as a bioactive compound.Therefore,this paper comprehensively reviews the latest development works(over the last 2-3 years)aiming at the extraction of cannabinoids and purification of CBD using traditional,emerging,and synergistic extraction techniques and strategies.Particular emphasis and discussion have been focused on the innovative extraction techniques and the relevant outcomes with detailed strategies to meet such high extraction rates.Biological properties(at lab-scale and clinical case studies),current practices,progress in legislation and commercialization of CBD are also overviewed.Finally,according to the findings of this review,the future trends and research gaps are also given.
基金
Financial support from Polish National Agency for Academic Exchange(NAWA)under Ulam Programme(Agreement No.PPN/ULM/2020/1/00005/U/00001)is gratefully acknowledged.R.Castro-Munoz also acknowledges the School of Engineering
Science and the FEMSA-Biotechnology Center at Tecnologico de Monterrey for their support through the Bioprocess(0020209I13)Focus Group.
