摘要
Annulus fibrosus(AF)plays a crucial role in the biomechanical loading of intervertebral disc(IVD).AF is difficult to self-heal when the annulus tears develop,because AF has a unique intricate structure and biologic milieu in vivo.Tissue engineering is promising for repairing AF rupture,but construction of suitable mechanical matching devices or scaffolds is still a grand challenge.To deeply know the varied forces involved in the movement of the native annulus is highly beneficial for designing biomimetic scaffolds to recreate the AF function.In this review,we overview six freedom degrees of forces and adhesion strength on AF tissue.Then,we summarize the mechanical modalities to simulate related forces on AF and to assess the characteristics of biomaterials.We finally outline some current advanced techniques to develop mechanically adaptable biomaterials for AF rupture repair.
基金
support for the work from the Ministry of Science and Technology of China(2020YFA0908900)
National Natural Science Foundation of China(21935011 and 21725403)
Shenzhen Science and Technology Innovation Commission(KQTD20200820113012029 and JCYJ20220818100601003)
Guangdong Basic and Applied Basic Research Foundation(2022A1515110321)
Guangdong Provincial Key Laboratory of Advanced Biomaterials(2022B1212010003).
