摘要
目的探讨氨溴索联合重组人干扰素α1b治疗小儿支气管肺炎的临床效果。方法选取2020年1月至2023年1月神木市医院收治的80例支气管肺炎患儿作为研究对象,按照随机数字表法分为对照组(40例)与观察组(40例)。对照组单用氨溴索治疗,观察组在对照组基础上联合重组人干扰素α1b治疗。比较两组肺功能、症状消失时间及不良反应发生情况。结果治疗后,两组最大呼气压、用力肺活量、呼气流量峰值及最大吸气压均升高,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组发热、咳嗽、气促及肺部啰音消失时间均短于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论氨溴索联合重组人干扰素α1b治疗小儿支气管肺炎的临床效果显著,可有效改善患儿肺功能,缩短症状消失时间,且不增加不良反应。
Objective To explore the clinical effect of Ambroxol combined with Recombinant Human Interferonα1b in the treatment of children with bronchial pneumonia.Methods A total of 80 children with bronchial pneumonia in Shenmu Hospital from January 2020 to January 2023 were selected as the research objects and divided into the control group(40 cases)and the observation group(40 cases)according to the random number table method.The control group was treated with Ambroxol alone,and the observation group was treated with Ambroxol combined with Recombinant Human Interferonα1b.The lung function,symptom disappearance time,and incidence of adverse reactions were compared between the two groups.Results After treatment,the maximal expiratory pressure,forced vital capacity,peak expiratory flow,and maximal inspiratory pressure in the both groups were increased,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The disappearance time of fever,cough,short breath,and lung rales in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of Ambroxol combined with Recombinant Human Interferonα1b in the treatment of children with bronchial pneumonia is significant,which can effectively improve lung function,shorten the symptom disappearance time,and does not increase adverse reactions.
作者
周占强
张晓梅
ZHOU Zhanqiang;ZHANG Xiaomei(Department of General Pediatrics,Shenmu Hospital,Shaanxi Province,Shenmu 719300,China)
出处
《妇儿健康导刊》
2024年第20期109-112,共4页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
关键词
氨溴索
重组人干扰素Α1B
小儿支气管肺炎
Ambroxol
Recombinant Human Interferonα1b
Children with bronchial pneumonia
