摘要
目的探讨直接冠脉注射替罗非班用于行经皮冠状动脉介入术(percutaneous coronary intervention,PCI)的急性心肌梗死(myocardial infarction,MI)患者中的效果。方法随机选取2020年1月—2024年2月江苏省宿迁市中医院收治的120例急性MI患者为研究对象,根据治疗方法不同分为对照组和观察组,每组60例。对照组采用PCI术治疗,观察组采用PCI结合直接冠脉注射替罗非班治疗,比较两组的心功能、术后1 h ST回落率、不良反应发生率及冠脉再通率。结果治疗后,观察组的心功能指标优于对照组,差异有统计学意义(P<0.05)。观察组的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。观察组的术后1 h ST回落率为95.00%(57/60),冠脉总再通率为93.33%(56/60),高于对照组的63.33%(38/60)和65.00%(39/60),差异有统计学意义(χ^(2)=18.240、14.602,P均<0.05)。结论直接冠脉注射替罗非班对行PCI的急性MI患者心功能改善明显,可预防不良事件,提高冠脉再通率。
Objective To investigate the effect of direct coronary injection of tirofiban in patients with acute myocar⁃dial infarction(MI)undergoing percutaneous coronary intervention(PCI).Methods A total of 120 patients with acute MI admitted to Suqian Traditional Chinese Medicine Hospital of Jiangsu Province from January 2020 to February 2024 were randomly selected as the research objects,and they were divided into control group and observation group according to different treatment methods,with 60 cases in each group.The control group was treated with PCI,and the observation group was treated with PCI combined with direct coronary injection of tirofiban.The cardiac function,ST fall rate at 1 hour after operation,incidence of adverse reactions and coronary recanalization rate were compared be⁃tween the two groups.Results After treatment,the cardiac function index of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).The total ST drop rate at 1 hour after operation in the observation group was 95.00%(57/60),and the total coronary re⁃canalization rate was 93.33%(56/60),which was higher than 63.33%(38/60)and 65.00%(39/60)in the control group,the differences were statistically significant(χ^(2)=18.240,14.602,both P<0.05).Conclusion Direct coronary injection of tirofiban can significantly improve cardiac function in patients with acute MI undergoing PCI,prevent adverse events and improve coronary recanalization rate.
作者
蔡文明
史波
叶小彬
CAI Wenming;SHI Bo;YE Xiaobin(Department of Cardiovascular Medicine,Suqian Traditional Chinese Medicine Hospital of Jiangsu,Suqian,Jiangsu,223800,China)
出处
《中外医疗》
2024年第30期78-81,共4页
China & Foreign Medical Treatment
关键词
替罗非班
经皮冠状动脉介入术
心肌梗死
心功能
Tirofiban
Percutaneous coronary intervention
Myocardial infarction
Cardiac function
