摘要
大气中的颗粒物2.5(PM_(2.5))是空气污染的主要成分之一,其危害已引起全球关注。PM_(2.5)不仅对呼吸系统、心血管系统和神经系统造成损伤,还对生殖系统产生不良影响。男性生殖系统是维持人类生殖能力和繁衍后代的组成部分。随着全球不孕不育症发生率逐年递增,人们对PM_(2.5)对男性生殖系统的潜在危害给予了高度关注。PM_(2.5)能够进入男性生殖系统并累积其中,对生殖细胞产生直接不良反应,诱发细胞凋亡、氧化应激和DNA损伤等病理过程,导致精子质量下降。PM_(2.5)还可干扰生殖激素的合成、释放和受体结合,影响生殖激素的正常调节功能,进而影响精子生成和生存环境。PM_(2.5)主要通过多种信号通路来诱导男性生殖系统损伤。该文从分子信号通路方面综合梳理已有的研究成果,进一步阐明这些信号通路机制,以深入了解PM_(2.5)对男性生殖损伤的影响,并为制订有针对性的预防和治疗策略提供参考。
Particulate matter 2.5(PM_(2.5))in the atmosphere is one of the main components of air pollution,and its harm has attracted global attention.PM_(2.5) not only causes the damage of respiratory,cardiovascular and nervous systems,but also generates the adverse effect on the reproductive system.The male reproductive system is a component of maintaining human fertility and reproducing offspring.With the incidence rate of global infertility increasing year by year,people have paid great attention to the potential harm of PM_(2.5) to the male reproductive system.PM_(2.5) can enter the male reproductive system and accumulate in it,causing the direct adverse reactions to germ cells,inducing pathological processes such as apoptosis,oxidative stress and DNA damage,resulting in a decrease in sperm quality.PM_(2.5) can also interfere with the synthesis,release and receptor binding of reproductive hormones,affecting the normal regulatory function of reproductive hormones,and then affecting spermatogenesis and living environment.PM_(2.5) mainly induces the damage to the male reproductive system through a variety of signaling pathways.This paper further elucidates the maechanism of these signal pathways by comprehensively teasing the existing research results from the aspect of molecular signaling pathways,so as to deeply understand the impact of PM_(2.5) on male reproductive injury and provide reference for formulating the targeted prevention and treatment strategies.
作者
王操
刘斌
WANG Cao;LIU Bin(Department of Pediatric Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China;Department of Pediatric Surgery,Longgang Maternal and Child Health Care Hospital,Shenzhen,Guangdong 518172,China)
出处
《重庆医学》
CAS
2024年第20期3156-3160,3167,共6页
Chongqing Medical Journal
基金
国家自然科学基金项目(82060277)
贵州省卫生健康委员会基金项目(gzwjkj2023-413)
合肥市科技计划项目[遵市科合HZ字(2023)238号]。
关键词
颗粒物2.5
生殖损伤
分子机制
氧化应激
细胞凋亡
综述
particulate matter 2.5
reproductive injury
molecular mechanisms
oxidative stress
apoptosis
review
