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间充质干细胞对脊髓损伤后巨噬细胞极化的调节作用及途径 被引量：1

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摘要 脊髓损伤导致中枢神经系统严重受损,继发性炎症反应在损伤发展过程中起关键作用,损伤部位M1型、M2型巨噬细胞比例失衡是炎症持续的主要因素。间充质干细胞通过凋亡小体、旁分泌作用、外泌体及其负载的微小RNA、基因修饰、相关信号通路(Janus激酶/信号传递与转录因子通路、Notch通路、磷脂酰肌醇3-激酶/蛋白激酶B通路)调节巨噬细胞的极化,保持M1型和M2型巨噬细胞的平衡,从而抑制炎症反应,促进神经功能恢复。
作者 毕晶晶 余明阳 李诚
机构地区 海军军医大学第一附属医院关节骨病外科
出处 《山东医药》 CAS 2024年第31期112-115,共4页 Shandong Medical Journal
关键词 脊髓损伤 间充质干细胞 巨噬细胞 极化
分类号 R744 [医药卫生—神经病学与精神病学]
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山东医药
2024年 第31期

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