摘要
缝隙连接蛋白(Connexin,Cx)是一种介导细胞间信息交流与物质交换的跨膜蛋白,其功能和表达的改变[如异常表达、亚细胞定位改变及缝隙连接细胞间通讯(Gap junction intercellular communication,GJIC)缺失]常参与多种肿瘤的发生发展。缝隙连接蛋白26(Connexin 26,Cx26)是缝隙连接蛋白家族的重要成员,与癌症的关系复杂。在不同肿瘤组织中,Cx26以GJIC依赖性或GJIC非依赖性作用发挥抑癌或促癌作用。此外,Cx26与多种肿瘤预后相关,具有作为肿瘤预后标志物及抗肿瘤治疗靶点的巨大潜力。本文对Cx26与多种肿瘤的关系及机制进行综述,为Cx26作为抗肿瘤治疗的干预靶点提供思路。
Connexin(Cx)is a transmembrane protein that communicates intercellular information.Changes in its function and expression,such as abnormal expression,subcellular locolization changes,lack of gap junction intercellular communication(GJIC),are often involved in the occurrence and development of various tumors.Connexin 26(Cx26)is an important member of the connexin family and has a complex relationship with cancer.In different tumor tissues,Cx26 plays a tumor suppressor or tumor promoter role in GJIC-dependent or GJIC-independent manner.In addition,Cx26 is a variety of tumor prognostic factors and has great potential as a tumor prognostic marker and anti-tumor therapeutic target.This article reviews the relationship and mechanism between Cx26 and various tumors,aiming to provide some ideas for Cx26 as an intervention target for anti-tumor therapy.
作者
潘科华
丁一峰
舒飞
刘清泉
PAN Ke-hua;DING Yi-feng;SHU Fei;LIU Qing-quan(Gannan Medical University;Department of Hepatobiliary Surgery,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)
出处
《赣南医科大学学报》
2024年第9期891-898,共8页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
国家自然科学基金资助项目(82060505)
江西省自然科学基金资助项目(20232BAB206106)。
