摘要
目的 针对三七药材种植过程中农药施用的情况,对三七中常用农药及法规监管的农药进行全面筛查,摸清其农药残留污染情况,并进行相关风险评估研究。根据《GB 2763-2021食品安全国家标准食品中农药最大残留限量》和《中国药典》2020年版的相关技术要求,制订相关农药的限量标准,并建立相应农药残留测定方法。方法 采用气相色谱-串联质谱法(GC-MS/MS)和液相色谱-串联质谱法(LC-MS/MS),建立三七中法规监管的常用农药检测方法;依法对收集的三七样本进行全面筛查和风险评估;并根据GB 2763限量标准中三七涉及的农药转化农药指标。结果 本研究成功建立了三七中115种常用农药及法规规定的禁用农药的残留测定方法,并根据我国食品中农药最大残留限量标准GB 2763转化相应的限量标准。最终确认了包括戊唑醇、苯醚甲环唑及多菌灵等在内的8种农药作为转化农药指标。结论 本研究建立的三七农药残留检测方法具有操作简便快速、专属性强和灵敏度高的特点,相关风险评估及限量制订工作为三七质量标准的完善提供技术支持。
OBJECTIVE To carry out screening of pesticide residues in Panax notoginseng for the pesticide residues commonly used in Panax notoginseng,understand the pesticide residues situation and carry out the related risk assenssment study.METHODS GC-MS/MS and LC-MS/MS methods were used to establish detection methods for commonly used pesticides in Panax notoginseng,as well as those regulated by laws and regulations;the methods were used to conduct a comprehensive screening and risk assessment of the collected Panax notoginseng samples;and the indexes of the transformed pesticides were confirmed in accordance with the pesticide residue limits of Panax notoginseng in the GB 2763 standard.RESULTS In this study,the residue determination methods for about 40 commonly used pesticides and pesticides regulated by regulations in Panax notoginseng were successfully established,and the corresponding limits were set according to the GB 2763 standard.Eight pesticides including tebuconazole,phenyl ether metronidazole and carbendazim were finally recognized as transformed pesticide indicators.CONCLUSION The pesticide residue detection method for Panax notoginseng established in this study is characterized by simple and rapid operation,high specificity and high sensitivity,and the related risk assessment and limit setting provide technical support for the improvement of the quality standard of Panax notoginseng.
作者
李雯婷
陈艳芳
杨新华
兰岚
苗水
毛秀红
胡青
LI Wenting;CHEN Yanfang;YANG Xinhua;LAN Lan;MIAO Shui;MAO Xiuhong;HU Qing(Key Laboratory for Quality Control of Traditional Chinese Medicine,Shanghai Institute for Food and Drug Control,Shanghai 201203,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2024年第16期1478-1487,共10页
Chinese Pharmaceutical Journal
基金
国家药品监督管理局药品监管科学体系建设重点项目资助(RS2024Z006-110)
药品监管科学全国重点实验室课题资助(2023SKLDRS0103)
2024年度国家药品标准制修订研究课题资助(2024Z01,2024Z03)
上海市中药和保健食品品质与安全检测专业技术服务平台资助(21DZ2290200)。
关键词
三七
农药残留
检测方法
风险评估
限量标准转化
Panax notoginseng
pesticide residue
detection method
risk assessment
transformation of limit standards
