摘要
研究了红霉素肟硅醚化绿色合成工艺。以红霉素A肟为原料,盐酸甲醇为催化剂,进行硅醚化反应,并优化了反应条件。优化条件下,硅醚化反应收率96.4%,产品纯度94.4%。该工艺可以替代现有盐酸吡啶为催化剂的硅烷化反应,达到绿色合成、降低原辅料成本、并减少三废的目的,适合工业化生产。
The research aims to develop a green synthesis method for the silicon etherification of erythromycin oxime.Using erythromycin A oxime as the raw material and methanol hydrochloride as the catalyst,the silicon etherification reaction was carried out and the reaction conditions were optimized.After optimization,the yield of silicon etherification reaction was 96.4%and the purity of the product was 94.4%.This process offers a sustainable alternative to silanization reaction with pyridine hydrochloride as catalyst,achieving green synthesis,reducing raw material costs,minimizing waste,and making it suitable for industrial production.
作者
单继雷
汤旗
曹塞北
金勇
卢标华
李广青
SHAN Ji-lei;TANG Qi;CAO Sai-bei;JIN Yong;LU Biao-hua;LI Guang-qing(Zhejiang Guobang Pharmaceutical Co.,Ltd.,Shangyu 312369,China)
出处
《精细化工中间体》
CAS
2024年第4期39-41,共3页
Fine Chemical Intermediates
关键词
红霉素A肟
硅醚化反应
盐酸甲醇
绿色合成
erythromycin A oxime
silicon etherification reaction
methanol hydrochloride
green synthesis
