摘要
目的分析体外受精-胚胎移植(IVF-ET)解冻周期中移植不同胚胎数目对临床妊娠率和妊娠结局的影响,探讨单胚胎移植技术在不同年龄女性中应用的临床意义。方法回顾性分析2019年1月—2020年12月于枣庄市妇幼保健院行冻融胚胎移植周期的1865例患者。将所有患者按年龄分为4组,1组年龄<30岁,2组年龄30~34岁,3组年龄35~39岁,4组年龄40~42岁。每组患者按移植胚胎数分为两组,A组移植1个胚胎,B组移植2个胚胎,比较A组和B组的临床妊娠率和活产率。结果1组:A组临床妊娠率(62.79%)明显低于B组临床妊娠率(74.15%),差异有统计学意义(χ^(2)=4.414,P<0.05),A组活产率(54.65%)和B组活产率(64.20%)比较差异无统计学意义(χ^(2)=2.686,P>0.05)。2组:A组临床妊娠率(58.21%)及活产率(52.24%)均低于B组(临床妊娠率:68.55%,活产率:58.20%),差异均有统计学意义(χ^(2)=6.850,6.365,均P<0.05)。3组及4组:A组临床妊娠率及活产率均低于B组,但差异均无统计学意义(均P>0.05)。结论针对年龄30岁以下的患者,单胚胎移植和双胚胎移植相比,临床妊娠率降低,但是活产率无明显差异。对于年龄35岁以上的患者,单胚胎移植和双胚胎移植的妊娠率及活产率均无明显差异。
Objective To analyze the effects of different embryo numbers in thawing cycle of in vitro fertilization and embryo transfer(IVF-ET)on clinical pregnancy rate and pregnancy outcomes,explore the clinical significance of single embryo transfer technique in women of different ages.Methods A total of 1865 patients of freeze-thaw embryo transfer cycle in Zaozhuang Municipal Maternal and Child Health Care Hospital from January 2019 to December 2020 were analyzed retrospectively.All the patients were divided into four groups ac-cording to age:group one(less than 30 years old),group two(30-34 years old),group three(35-39 years old),and group four(40-42 years old).The patients in each group were divided into four subgroups,the patients in group A were transferred for one embryo,and the patients in group B were transferred for two embryos.The clinical pregnancy rates and live birth rates in group A and group B were com-pared.Results Group one:the clinical pregnancy rate in group A was 62.79%,which was lower than that in group B(74.15%),there was statistically significant difference(χ^(2)=4.414,P<0.05),there was no statistically significant difference in live birth rate between group A(54.65%)and group B(64.20%)(χ^(2)=2.686,P>0.05).Group two:the clinical pregnancy rate and live birth rate in group A were 58.21%and 52.24%,which were lower than those in group B(68.55%,58.20%),there were statistically significant differences(χ^(2)=6.850,6.365,P<0.05).Group three and group four:the clinical pregnancy rate and live birth rate in group A were lower than those in group B,but there was no statistically significant difference(P>0.05).Conclusion For the patients under 30 years old,compared with two-embryo transfer,the clinical pregnancy rate of single embryo transfer decreases,but there was no statistically significant difference in live birth rate.For the patients more than 35 years old,there was no statistically significant difference in clinical pregnancy rate and live birth rate between two-embryo transfer and single embryo transfer.
作者
王可可
张兴兴
王磊
WANG Ke-ke;ZHANG Xing-xing;WANG Lei(Zaozhuang Municipal Maternal and Child Health Care Hospital,Zaozhuang,Shandong 277100,China)
出处
《中国妇幼保健》
CAS
2024年第16期3079-3082,共4页
Maternal and Child Health Care of China
基金
山东省妇幼保健协会科技创新科研项目(鲁妇幼协发[2021]19号)。
关键词
胚胎移植
活产率
临床妊娠率
Embryo transfer
Live birth rate
Clinical pregnancy rate
