摘要
注射用原位凝胶作为一种较新的剂型,具有能够长效释放、病灶局部给药、防止药物滥用和误用等优势,具有广阔的应用前景。注射用原位凝胶在注射前具有较低黏度,易通过注射器,并在注射后由于体内环境因素影响在注射部位形成药物贮库。本文综述了注射用原位凝胶的4种主要类型,并对其基质材料方面的进展进行了总结,旨在为此类制剂的设计和优化提供参考。
Injectable in situ gel,as a relatively new dosage form,has a broad prospect because of its characteristics of sustained and prolonged release action,local administration at lesion site,and prevention of drug abuse and misuse.Injectable in situ gel can be passed through hypodermic needle with low applied pressure because of its low viscosity and drug reservoir is formed at the injection site due to external environmental stimuli.This review summarizes four main types of injectable in situ gel and discusses recent progress focusing on the gelling materials and drug release,aiming to provide reference for design and optimization of such preparations.
作者
蒋元
严真
杨磊
尹莉芳
JIANG Yuan;YAN Zhen;YANG Lei;YIN Lifang(Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Engineering Research Center for Development and Evaluation of Sustained-Release Intelligent Preparations and Key Functional Excipients of Jiangsu Province,Nanjing 210009,China)
出处
《药学研究》
CAS
2024年第8期806-814,共9页
Journal of Pharmaceutical Research
关键词
原位凝胶
长效注射剂
基质
药物贮库
In situ gel
Long-acting injection
Matrices
Drug depot
