摘要
目的:探讨柴胡桂枝干姜汤加减治疗晚期肺癌的临床疗效。方法:选择2021年10月—2023年4月于如皋市中医院就诊的晚期肺癌患者122例,采用随机数字表法分成常规组与中药组,每组61例。常规组采用卡瑞利珠单抗联合阿帕替尼治疗,中药组在常规组的基础上采用柴胡桂枝干姜汤加减治疗。观察两组患者的中医证候积分、血清学指标、肿瘤标志物、免疫功能、临床疗效、不良反应发生情况、癌症生存率分析。结果:治疗后,中药组患者中医证候积分、微小RNA-498(miR-498)、miR-1269、干扰素诱导蛋白10(IP-10)水平、癌胚抗原(CEA)及胸苷激酶(TK1)水平均低于常规组(P<0.01);中药组CD4^(+)、CD4^(+)/CD8^(+)均高于常规组(P<0.01),中药组CD8^(+)低于常规组(P<0.01);中药组患者疾病控制率高于常规组(P<0.01);两组不良反应总发生率差异无统计学意义(P>0.05);中药组PFS长于常规组(P<0.01)。结论:柴胡桂枝干姜汤加减联合卡瑞利珠单抗联合阿帕替尼能够改善患者血清学指标,降低中医证候积分及肿瘤标志物水平,提高患者免疫功能及临床疗效,安全性较高。
Objective:To investigate the clinical effect of modified bupleurum,cinnamon twig and dried ginger decoction in the treatment of advanced lung cancer.Methods:A hundred and twenty-two patients with advanced lung cancer treated in Rugao Hospital of Traditional Chinese Medicine from October 2021 to April 2023 were selected and divided into conventional group and Chinese herbal medicine group by random number table method,with 61 cases in each group.The conventional group was treated with carolizumab and apatinib,while the Chinese herbal medicine group was treated with the same plus modified modified bupleurum,cinnamon twig and dried ginger decoction.TCM syndrome score,serological index,tumor markers,immune function,clinical efficacy,occurrence of adverse reactions and cancer survival rate were observed in the two groups.Results:After treatment,TCM syndrome scores,micrornA-498(miR-498),miR-1269,interferon-induced protein 10(IP-10),carcinoembryonic antigen(CEA)and thymidine kinase(TK1)levels in Chinese herbal medicine group were lower than those in conventional group(P<0.05).CD4^(+),CD4^(+)/CD8^(+)in Chinese herbal medicine group were higher than those in conventional group(P<0.05),and CD8^(+)in Chinese herbal medicine group was lower than that in conventional group(P<0.05).The disease control rate in Chinese herbal medicine group was higher than that in conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).PFS in Chinese herbal medicine group was longer than that in combination group(P<0.05).Conclusion:Modified bupleurum,cinnamon twig and dried ginger decoction combined with carrilizumab and apatinib can improve patients serological indexes,reduce TCM syndrome scores and tumor markers,improve patients immune function and clinical efficacy,and have high safety.
作者
石建
刘杰
杨宇涵
薛刚
SHI Jian;LIU Jie;YANG Yuhan;XUE Gang(Department of Oncology,Rugao Hospital of Traditional Chinese Medicine,Nantong 226500,China)
出处
《中医药学报》
CAS
2024年第9期79-83,共5页
Acta Chinese Medicine and Pharmacology
基金
江苏省中医药科技发展计划项目(MS2023119)
南通市基础研究和民生科技计划指导性项目(MSZ21109)。
关键词
柴胡桂枝干姜汤
卡瑞利珠单抗
阿帕替尼
晚期肺癌
肿瘤标志物
Bupleurum,cinnamon twig and dried ginger decoction
Carrilizumab
Apatinib
Advanced lung cancer
Tumor markers
