摘要
新生儿败血症是常见的感染性疾病,病情严重,病死率高。其发病机制复杂,缺乏特异性表现,培养阳性率低,早期诊断和个体化治疗仍然是临床医生面临的挑战。对双胞胎的流行病学研究表明,遗传因素与新生儿败血症存在关联。基因多态性与其易感性、病情发展和预后密切相关。该文就新生儿败血症相关的白细胞介素、肿瘤坏死因子、Toll样受体、NOD样受体、CD14、髓系细胞触发受体1、甘露糖结合凝集素和其他免疫蛋白基因多态性进行综述,以期促进该疾病的精准医疗。
Neonatal sepsis is a common and severe infectious disease with a high mortality rate.Its pathogenesis is complex,lacks specific manifestations,and has a low positive culture rate,making early diagnosis and personalized treatment still a challenge for clinicians.Epidemiological studies on twins have shown that genetic factors are associated with neonatal sepsis.Gene polymorphisms are closely related to susceptibility,disease development,and prognosis.This article provides a review of gene polymorphisms related to neonatal sepsis,including interleukins,tumor necrosis factor,Toll-like receptors,NOD-like receptors,CD14,triggering receptor expressed on myeloid cells-1,mannose-binding lectin,and other immune proteins,aiming to promote precision medicine for this disease.
作者
高静(综述)
舒剑波
刘洋(审校)
GAO Jing;SHU Jian-Bo;LIU Yang(Department of Neonatology,Longyan Campus,Tianjin Children's Hospital/Tianjin University Children's Hospital,Tianjin 300134,China)
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2024年第8期879-886,共8页
Chinese Journal of Contemporary Pediatrics
基金
天津市教委科研计划项目(2022YGYB12)
天津市科技计划项目(21JCYBJC00370)
天津市医学重点学科(专科)建设项目(TJYXZDXK-040A)。
关键词
败血症
遗传易感性
基因多态性
单核苷酸多态性
新生儿
Sepsis
Genetic susceptibility
Gene polymorphism
Single nucleotide polymorphism
Neonate
