摘要
沸石咪唑骨架-8(ZIF-8)是一种金属-有机框架材料,具有独特的理化性质,基于ZIF-8作为主体结合大量客体信号分子的信号放大策略是开发新型检测方法的有前景的研究方向之一。生物标志物的准确、灵敏的检测方法的开发以及揭示其与各种疾病之间的联系是近年来的研究热点。基于ZIF-8构建的生物传感器能够高灵敏度、快速响应、低成本、高选择性地检测生物标志物,可以为医疗卫生工作中疾病的筛查、诊断、预后工作提供一种新的思路。
Zeolitic imidazolate framework-8(ZIF-8)is a metal-organic framework material with unique physical and chemical properties.The signal amplification strategy based on ZIF-8 as the host combined with a large number of vip signal molecules is one of the promising research directions for the development of novel detection methods.In recent years,the development of accurate and sensitive detection methods for biomarkers and the revelation of their association with various diseases have become a research hotspot.The biosensor based on ZIF-8 can detect biomarkers with high sensitivity,rapid response,low cost and high selectivity,which can provide a new way of thinking for disease screening,diagnosis and prognosis in medical and health care work.
作者
范炳华
张建军
刘越
吴拥军
王艺琳
FAN Binghua;ZHANG Jianjun;LIU Yue;WU Yongjun;WANG Yilin(College of Public Health,Zhengzhou University,Zhengzhou 450001,China;Food Safety and Emergency Support Center,Administration for Market Regulation Henan Province,Zhengzhou 450000,China;Henan Institute of Food and Salt Industry Inspection Technology,Zhengzhou 450000,China)
出处
《生物化工》
CAS
2024年第3期226-228,共3页
Biological Chemical Engineering
基金
国家市场监督管理总局技术保障专项项目(2023YJ20)
河南省自然科学基金项目(222300420302)。
