摘要
目的 建立武汉地区表观健康成人血清可溶性转铁蛋白受体(soluble transferrin receptor,sTfR)和可溶性转铁蛋白受体与血清铁蛋白常用对数的比值(sTfR/log serum ferritin index,sTfR/lgSF)参考区间,为临床对铁缺乏和缺铁性贫血诊治提供依据。方法 选取武汉亚心总医院表观健康体检者和献血屋献血者273名,检测sTfR、其他铁代谢指标以及超敏C-反应蛋白(high sensitivity C-reactive protein,hsCRP),并计算sTfR/lgSF值,采用百分位数法(P2.5~P97.5)建立sTfR和sTfR/lgSF参考区间。采用Spearman相关分析评价sTfR、sTfR/lgSF与其他铁代谢指标、hsCPR相关性。结果 sTfR水平(M,mg/L)男女(1.01 vs 1.07)间差异不具统计学意义(P>0.05),但男性sTfR/lgSF水平明显低于女性(0.45 vs 0.62),差异有统计学意义(P<0.05);各年龄组间sTfR(M,mg/L)、sTfR/lgSF(M)比较,分别为(1.07 vs 1.02 vs 1.00)、(0.52 vs 0.53 vs 0.51),差异均不具统计学意义(P>0.05);sTfR参考区间为(0.72~1.68)mg/L,根据性别建立sTfR/lgSF参考区间为男性(0.31~0.88)、女性(0.37~1.19);相关性分析结果显示:sTfR、sTfR/lgSF与hsCRP无相关性(r=0.043,P>0.05)、(r=-0.064,P>0.05),而血清铁蛋白(serum ferritin,SF)、血清铁(serum iron,SI)、转铁蛋白饱和度(transferrin saturation,TSAT)与hsCRP均有相关性(r=0.128,P<0.05)、(r=-0.195,P<0.01)、(r=-0.173,P<0.01);sTfR与SF无相关性(r=-0.115,P>0.05),而sTfR/lgSF与SF有显著性相关(r=-0.685,P<0.01)。结论 初步建立了武汉地区表观健康成人血清sTfR及sTfR/lgSF的参考区间。sTfR和sTfR/lgSF不受炎性因子影响,对在炎症作用下血清铁蛋白升高的贫血患者,鉴别是否存在铁缺乏方面有着重大意义。
Objective To establish reference intervals for serum soluble transferrin receptor(sTfR) and sTfR/log serum ferritin index(sTfR/lgSF) in apparently healthy adults in the Wuhan area,so as to provide reference for clinical diagnosis and treatment of iron deficiency and iron-deficiency anemia.Methods A total of 273 individuals from the Wuhan Aisa General Hospital,including health examination participants and blood donors,were selected to measure sTfR,other iron metabolism indicators and high sensitivity C-reactive protein(hsCRP).The sTfR/lgSF values were calculated and reference intervals for sTfR and sTfR/lgSF were established using the percentile method(P2.5 to P97.5).Spearman correlation analysis was used to evaluate the relationships between sTfR,sTfR/lgSF,and other iron metabolism indicators,as well as hsCRP.Results The sTfR levels(M,mg/L) between males and females(1.01 vs 1.07) were not statistically significant(P>0.05),but the sTfR/lgSF levels if males were significantly lower than those in females(0.45 vs 0.62)(P<0.05).There was no significant difference in sTfR(M,mg/L) and sTfR/lgSF(M) among different age groups,with values of 1.07 vs 1.02 vs 1.00 and 0.52 vs 0.53 vs 0.51,respectively(P>0.05).The reference interval for STfR was(0.72-1.68) mg/L,the sTfR/lgSF reference interval was(0.31-0.88) for males,and(0.37-1.19) for females.Correlation analysis showed no correlation between sTfR,sTfR/lgSF and hsCRP(r=0.043,P>0.05;r=-0.064,P>0.05),while serum ferritin(SF),serum iron(SI),transferrin saturation(TSAT)were correlated with hsCRP(r=0.128,P<0.05;r=-0.195,P<0.01;r=-0.173,P<0.01).There was no correlation between sTfR and SF(r=-0.115,P>0.05),while sTfR/lgSF was significantly correlated with and SF(r=-0.685,P<0.01).Conclusion Preliminary reference intervals for serum sTfR and sTfR/lgSF in apparently healthy adults in the Wuhan has been established.sTfR and sTfR/lgSF are not affected by inflammatory factors and are significant for identifying iron deficiency in anemia patients with elevated serum ferritin caused by inflammation.
作者
陶翠华
董杉杉
凃茹
李然
李玲
曹树正
TAO Cuihua;DONG Shanshan;TU Ru;LI Ran;LI Ling;CAO Shuzheng(Department of Transfusion Medicine,Wuhan Aisa General Hospital,Wuhan 430022,China;Department of Transfusion Medicine,Wuhan Asia Heart Hospital;Department of Clinical Laboratory,Wuhan Asia Heart Hospital)
出处
《中国输血杂志》
CAS
2024年第7期807-811,共5页
Chinese Journal of Blood Transfusion
基金
武汉市卫健委科研项目资助(WX23A74)
武汉亚心总医院资金项目(2022KYCX1-B08)。
