摘要
目的:观察噻托溴铵吸入剂治疗老年稳定期慢性阻塞性肺疾病(COPD)的效果。方法:选取2022年1月—2023年5月贵阳市云岩区圣泉社区卫生服务中心收治的老年稳定期COPD患者60例为研究对象,随机分为对照组和研究组,各30例。两组均实施常规支持疗法,对照组在常规支持疗法基础上采用吸入用异丙托溴铵溶液治疗,研究组在常规支持疗法基础上采用噻托溴铵粉雾剂治疗。比较两组肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、FEV_(1)/FVC]、治疗效果、生活质量、不良反应发生率。结果:治疗前,两组FVC、FEV_(1)、FEV_(1)/FVC比较,差异无统计学意义(P>0.05);治疗后,两组FVC、FEV_(1)、FEV_(1)/FVC高于治疗前,研究组高于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P=0.030)。治疗前,两组心理功能、社会功能、物质生活及躯体功能评分比较,差异无统计学意义(P>0.05);治疗后,两组心理功能、社会功能、物质生活及躯体功能评分高于治疗前,研究组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:噻托溴铵治疗老年稳定期COPD效果较好,可提高肺功能及生活质量,且安全性高。
Objective:To observe the effect of tiotropium bromide inhalant on stable chronic obstructive pulmonary disease(COPD)in the elderly.Methods:Sixty elderly patients with stable COPD admitted to Guiyang Yunyan District Shengquan Community Health Service Center from January 2022 to May 2023 were selected as the study objects,and were randomly divided into control group and study group,with thirty cases in each group.Both groups received conventional supportive therapy.The control group was treated with inhaled ipratropium bromide solution on the basis of conventional supportive therapy,and the study group was treated with tiotropium bromide powder aerosol on the basis of conventional supportive therapy.The pulmonary function[forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1)),FEV_(1)/FVC],treatment effect,quality of life and incidence of adverse reactions were compared between the two groups.Results:Before treatment,there was no significant difference in FVC,FEV_(1) and FEV_(1)/FVC between the two groups(P>0.05);after treatment,FVC,FEV_(1) and FEV_(1)/FVC in two groups were higher than before treatment,and the study group was higher than the control group,the difference was statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P=0.030).Before treatment,there was no significant difference in the scores of psychological function,social function,material life and physical function between the two groups(P>0.05);after treatment,the scores of psychological function,social function,material life and physical function of the two groups were higher than before treatment,and the study group was higher than the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tiotropium bromide is effective in the treatment of stable COPD in the elderly,can improve lung function and quality of life,and has high safety.
作者
李俊
Li Jun(Guiyang Yunyan District Shengquan Community Health Service Center,Guiyang 550008,Guizhou Province,China)
出处
《中外医药研究》
2024年第15期27-29,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
噻托溴铵吸入剂
稳定期
慢性阻塞性肺疾病
Tiotropium bromide inhalant
Stable period
Chronic obstructive pulmonary disease
