摘要
目的:分析二甲双胍联合胰岛素治疗妊娠糖尿病的临床效果。方法:选取2022年1-12月武威市中医医院妇产科收治的妊娠糖尿病患者80例作为研究对象,根据随机数字表法分为两组,各40例。对照组采用胰岛素治疗,联合组在对照组基础上采用二甲双胍治疗。比较两组血糖水平、负面情绪评分、胰岛β细胞功能、不良妊娠结局发生情况、新生儿不良结局发生情况。结果:治疗前,两组空腹血糖(FPG)、餐后2h血糖(2hFPG)、糖化血红蛋白(HbA1c)水平比较,差异无统计学意义(P>0.05);治疗后,两组FPG、2hFPG、HbA1c水平低于治疗前,且联合组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分比较,差异无统计学意义(P>0.05);治疗后,两组SAS、SDS评分低于治疗前,且联合组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组空腹胰岛素水平、胰岛素抵抗指数比较,差异无统计学意义(P>0.05);治疗后,两组空腹胰岛素水平、胰岛素抵抗指数低于治疗前,且联合组低于对照组,差异有统计学意义(P<0.05)。联合组不良妊娠结局总发生率低于对照组,差异有统计学意义(P=0.047)。联合组新生儿不良结局总发生率低于对照组,差异有统计学意义(P=0.025)。结论:二甲双胍联合胰岛素治疗妊娠糖尿病的临床效果良好,可降低患者血糖水平,改善负面情绪、胰岛β细胞功能,减少不良妊娠结局、新生儿不良结局。
Objective:To analyze the clinical effect of metformin combined with insulin in treatment of gestational diabetes mellitus.Methods:A total of 80 patients with gestational diabetes mellitus who were admitted to the Department of Obstetrics and Gynecology of Wuwei Traditional Chinese Medicine Hospital from January 2022 to December 2022 were selected as study subjects.According to the random number table method,they were divided into two groups,with 40 cases in each group.The control group was treated with insulin,and the combination group was treated with metformin on the basis of the control group.Blood glucose levels,negative emotion scores,isletβcell function,adverse pregnancy outcome,and neonatal adverse outcome were compared between the two groups.Results:Before treatment,there was no significant difference in fasting blood glucose(FPG),2 h postprandial blood glucose(2 hFPG)and glycosylated hemoglobin(HbA1c)levels between the two groups(P>0.05).After treatment,the levels of FPG,2 hFPG and HbA1c in the two groups were lower than those before treatment,the levels in the combination group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the scores of Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)between the two groups(P>0.05).After treatment,the scores of SAS and SDS in the two groups were lower than those before treatment,the scores in the combination group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in fasting insulin level and insulin resistance index between the two groups(P>0.05).After treatment,the fasting insulin level and insulin resistance index in the two groups were lower than those before treatment,these indicators in the combination group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse pregnancy outcome in the combination group was lower than that in the control group,and the difference was statistically significant(P=0.047).The overall incidence of neonatal adverse outcome in the combination group was lower than that in the control group,and the difference was statistically significant(P=0.025).Conclusion:Metformin combined with insulin has a good clinical effect in the treatment of gestational diabetes mellitus,and can reduce blood glucose levels,improve negative emotions and isletβcell function,and reduce adverse pregnancy outcomes and neonatal adverse outcomes.
作者
陈秀梅
王财年
Chen Xiumei;Wang Cainian(Wuwei Traditional Chinese Medicine Hospital,Wuwei 733000,Gansu Province,China)
出处
《中国社区医师》
2024年第13期6-8,共3页
Chinese Community Doctors
关键词
二甲双胍
胰岛素
妊娠糖尿病
Metformin
Insulin
Gestational diabetes mellitus
